Detailed information of TA system TA166744

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 164712..165214
• Replicon: plasmid pIAE1
• Accession: NZ_CP058410
• Organism: Trichlorobacter lovleyi strain IAE

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FY034_RS18205
• Protein ID: WP_265552565.1
• Coordinates: 164712..164966 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: FY034_RS18210
• Protein ID: WP_265555334.1
• Coordinates: 164963..165214 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY034_RS18190 (FY034_18210)	159993..162623	+	2631	WP_265555329.1	UvrD-helicase domain-containing protein	-
FY034_RS18195 (FY034_18215)	162604..163941	-	1338	WP_224963446.1	transposase	-
FY034_RS18200 (FY034_18220)	164173..164670	+	498	WP_265555332.1	alpha/beta hydrolase	-
FY034_RS18205 (FY034_18225)	164712..164966	-	255	WP_265552565.1	Txe/YoeB family addiction module toxin	Toxin
FY034_RS18210 (FY034_18230)	164963..165214	-	252	WP_265555334.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FY034_RS18215 (FY034_18235)	165421..165732	+	312	Protein_183	cobalamin biosynthesis protein	-
FY034_RS18220 (FY034_18240)	165791..165940	+	150	Protein_184	hypothetical protein	-
FY034_RS18225 (FY034_18245)	166020..166571	-	552	WP_265555336.1	cob(I)yrinic acid a,c-diamide adenosyltransferase	-
FY034_RS18230 (FY034_18250)	166698..166991	+	294	Protein_186	hypothetical protein	-
FY034_RS18235 (FY034_18255)	167247..167447	-	201	WP_265555338.1	hypothetical protein	-
FY034_RS18240 (FY034_18265)	167956..168363	+	408	WP_265555340.1	pyridoxamine 5'-phosphate oxidase family protein	-
FY034_RS18245 (FY034_18270)	168457..168792	+	336	WP_265555342.1	DUF1516 family protein	-
FY034_RS18250 (FY034_18275)	168893..169846	+	954	WP_265555344.1	glutathione synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	sul1 / qacE	-	1..289634	289634

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9956.52 Da
• Isoelectric Point: 8.4984

>T166744 WP_265552565.1 NZ_CP058410:c164966-164712 [Trichlorobacter lovleyi]
MMIKFSTAAWEDYLYWQTTDKAMLKRINQLIRDIQREPFAGIGKPEPLKHQLAGFWSRRIDSCHRLVYAVEGDTLLIAQC
RDHY

Nucleotide

• Length: 255 bp

>T166744 NZ_CP074425:825270-825683 [Salmonella sp. SJTUF15034]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9391.56 Da
• Isoelectric Point: 5.5900

>AT166744 WP_265555334.1 NZ_CP058410:c165214-164963 [Trichlorobacter lovleyi]
MNALTYTYTRQHFAEVMKSVNEDHVPVVVTSQRGKPVVILSLDDFHAYEETAYLLRNPQGAKRLLESVEELRAGGGQTRD
LTE

Nucleotide

• Length: 252 bp

>AT166744 NZ_CP074425:825023-825289 [Salmonella sp. SJTUF15034]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA