Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 122345..124017 Replicon plasmid pIAE1
Accession NZ_CP058410
Organism Trichlorobacter lovleyi strain IAE

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag FY034_RS17980 Protein ID WP_265555689.1
Coordinates 122707..124017 (+) Length 437 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag FY034_RS17975 Protein ID WP_265555688.1
Coordinates 122345..122710 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY034_RS17930 (FY034_17950) 119935..120279 + 345 WP_265555686.1 HNH endonuclease -
FY034_RS17970 (FY034_17990) 121106..122212 + 1107 WP_265555687.1 RtcB family protein -
FY034_RS17975 (FY034_17995) 122345..122710 + 366 WP_265555688.1 helix-turn-helix transcriptional regulator Antitoxin
FY034_RS17980 (FY034_18000) 122707..124017 + 1311 WP_265555689.1 type II toxin-antitoxin system HipA family toxin Toxin
FY034_RS17985 (FY034_18005) 124032..124784 + 753 WP_265555690.1 DNA-directed RNA polymerase subunit alpha C-terminal domain-containing protein -
FY034_RS17990 (FY034_18010) 125095..125355 - 261 WP_265555691.1 hypothetical protein -
FY034_RS17995 (FY034_18015) 125537..125716 - 180 WP_265555692.1 hypothetical protein -
FY034_RS18000 (FY034_18020) 125703..126032 - 330 WP_265555693.1 hypothetical protein -
FY034_RS18005 (FY034_18025) 126091..126327 - 237 WP_265555695.1 hypothetical protein -
FY034_RS18010 (FY034_18030) 126331..126672 - 342 WP_265555696.1 hypothetical protein -
FY034_RS18015 (FY034_18035) 126693..127061 - 369 WP_265555697.1 hypothetical protein -
FY034_RS18020 (FY034_18040) 127054..127341 - 288 WP_265555699.1 hypothetical protein -
FY034_RS18025 (FY034_18045) 127328..127672 - 345 WP_265555701.1 hypothetical protein -
FY034_RS18030 (FY034_18050) 127676..128476 - 801 WP_265555703.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / qacE - 1..289634 289634


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-116)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-74)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 47969.54 Da        Isoelectric Point: 6.2468

>T166743 WP_265555689.1 NZ_CP058410:122707-124017 [Trichlorobacter lovleyi]
MSTVAEVKLWGKTIGAVVLEDGRDVALFEYDPAFVRSGIEVSPLEMPLSGGVYSFPALSRDSFHGLPGLLADSLPDKYGN
ALIDEWLALQGRLPGSMNAVERLCYTGSRGMGALEYLPATGPNRSKSATPVDIDRLVQLASEVLNRRGELQASFCNDDLT
ESALLDILRVGTSAGGARAKAIIAFNPETKEVRSGQVKAPIGFEYWLIKFDGVSGNKDKEKVSDPQGFGKIEYAYYLMAK
DCHIDMSECELLHENGRSHFMTKRFDRLPNGSKLHMQSLAALAHYDFNVAGVNSYEQAMMVCRRIGAPVGSIEQMFRRMA
FNIVARNQDDHVKNIAFLMDKKGSWALSPAFDMAYSYNPTGDWTDKHQMSMNGKRDGFAPDDFKECSRVAGLKQGQGLSI
LREVQSVVLNWPDYAGRAGIDEKTAESIAAAHRLSL

Download         Length: 1311 bp

>T166743 NZ_CP074425:358943-359218 [Salmonella sp. SJTUF15034]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13969.04 Da        Isoelectric Point: 10.2498

>AT166743 WP_265555688.1 NZ_CP058410:122345-122710 [Trichlorobacter lovleyi]
MRYNKNMKITSNLTDQTVLHELGERLARRRIELAKTQMQLAEESGLARRTIQYAEAGRSIQSESLVRLFRALGLFETLDA
LLPEQQVSPMDLLKLKKKARKRVRAAQVAQEAEDWQWGDES

Download         Length: 366 bp

>AT166743 NZ_CP074425:358680-358940 [Salmonella sp. SJTUF15034]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References