Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-couple_hipB |
| Location | 122345..124017 | Replicon | plasmid pIAE1 |
| Accession | NZ_CP058410 | ||
| Organism | Trichlorobacter lovleyi strain IAE | ||
Toxin (Protein)
| Gene name | HipA3 | Uniprot ID | - |
| Locus tag | FY034_RS17980 | Protein ID | WP_265555689.1 |
| Coordinates | 122707..124017 (+) | Length | 437 a.a. |
Antitoxin (Protein)
| Gene name | HipB3 | Uniprot ID | - |
| Locus tag | FY034_RS17975 | Protein ID | WP_265555688.1 |
| Coordinates | 122345..122710 (+) | Length | 122 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FY034_RS17930 (FY034_17950) | 119935..120279 | + | 345 | WP_265555686.1 | HNH endonuclease | - |
| FY034_RS17970 (FY034_17990) | 121106..122212 | + | 1107 | WP_265555687.1 | RtcB family protein | - |
| FY034_RS17975 (FY034_17995) | 122345..122710 | + | 366 | WP_265555688.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| FY034_RS17980 (FY034_18000) | 122707..124017 | + | 1311 | WP_265555689.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| FY034_RS17985 (FY034_18005) | 124032..124784 | + | 753 | WP_265555690.1 | DNA-directed RNA polymerase subunit alpha C-terminal domain-containing protein | - |
| FY034_RS17990 (FY034_18010) | 125095..125355 | - | 261 | WP_265555691.1 | hypothetical protein | - |
| FY034_RS17995 (FY034_18015) | 125537..125716 | - | 180 | WP_265555692.1 | hypothetical protein | - |
| FY034_RS18000 (FY034_18020) | 125703..126032 | - | 330 | WP_265555693.1 | hypothetical protein | - |
| FY034_RS18005 (FY034_18025) | 126091..126327 | - | 237 | WP_265555695.1 | hypothetical protein | - |
| FY034_RS18010 (FY034_18030) | 126331..126672 | - | 342 | WP_265555696.1 | hypothetical protein | - |
| FY034_RS18015 (FY034_18035) | 126693..127061 | - | 369 | WP_265555697.1 | hypothetical protein | - |
| FY034_RS18020 (FY034_18040) | 127054..127341 | - | 288 | WP_265555699.1 | hypothetical protein | - |
| FY034_RS18025 (FY034_18045) | 127328..127672 | - | 345 | WP_265555701.1 | hypothetical protein | - |
| FY034_RS18030 (FY034_18050) | 127676..128476 | - | 801 | WP_265555703.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | sul1 / qacE | - | 1..289634 | 289634 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 437 a.a. Molecular weight: 47969.54 Da Isoelectric Point: 6.2468
>T166743 WP_265555689.1 NZ_CP058410:122707-124017 [Trichlorobacter lovleyi]
MSTVAEVKLWGKTIGAVVLEDGRDVALFEYDPAFVRSGIEVSPLEMPLSGGVYSFPALSRDSFHGLPGLLADSLPDKYGN
ALIDEWLALQGRLPGSMNAVERLCYTGSRGMGALEYLPATGPNRSKSATPVDIDRLVQLASEVLNRRGELQASFCNDDLT
ESALLDILRVGTSAGGARAKAIIAFNPETKEVRSGQVKAPIGFEYWLIKFDGVSGNKDKEKVSDPQGFGKIEYAYYLMAK
DCHIDMSECELLHENGRSHFMTKRFDRLPNGSKLHMQSLAALAHYDFNVAGVNSYEQAMMVCRRIGAPVGSIEQMFRRMA
FNIVARNQDDHVKNIAFLMDKKGSWALSPAFDMAYSYNPTGDWTDKHQMSMNGKRDGFAPDDFKECSRVAGLKQGQGLSI
LREVQSVVLNWPDYAGRAGIDEKTAESIAAAHRLSL
MSTVAEVKLWGKTIGAVVLEDGRDVALFEYDPAFVRSGIEVSPLEMPLSGGVYSFPALSRDSFHGLPGLLADSLPDKYGN
ALIDEWLALQGRLPGSMNAVERLCYTGSRGMGALEYLPATGPNRSKSATPVDIDRLVQLASEVLNRRGELQASFCNDDLT
ESALLDILRVGTSAGGARAKAIIAFNPETKEVRSGQVKAPIGFEYWLIKFDGVSGNKDKEKVSDPQGFGKIEYAYYLMAK
DCHIDMSECELLHENGRSHFMTKRFDRLPNGSKLHMQSLAALAHYDFNVAGVNSYEQAMMVCRRIGAPVGSIEQMFRRMA
FNIVARNQDDHVKNIAFLMDKKGSWALSPAFDMAYSYNPTGDWTDKHQMSMNGKRDGFAPDDFKECSRVAGLKQGQGLSI
LREVQSVVLNWPDYAGRAGIDEKTAESIAAAHRLSL
Download Length: 1311 bp
>T166743 NZ_CP074425:358943-359218 [Salmonella sp. SJTUF15034]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA
Antitoxin
Download Length: 122 a.a. Molecular weight: 13969.04 Da Isoelectric Point: 10.2498
>AT166743 WP_265555688.1 NZ_CP058410:122345-122710 [Trichlorobacter lovleyi]
MRYNKNMKITSNLTDQTVLHELGERLARRRIELAKTQMQLAEESGLARRTIQYAEAGRSIQSESLVRLFRALGLFETLDA
LLPEQQVSPMDLLKLKKKARKRVRAAQVAQEAEDWQWGDES
MRYNKNMKITSNLTDQTVLHELGERLARRRIELAKTQMQLAEESGLARRTIQYAEAGRSIQSESLVRLFRALGLFETLDA
LLPEQQVSPMDLLKLKKKARKRVRAAQVAQEAEDWQWGDES
Download Length: 366 bp
>AT166743 NZ_CP074425:358680-358940 [Salmonella sp. SJTUF15034]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|