Detailed information of TA system TA166740

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 1073351..1074052
• Replicon: chromosome
• Accession: NZ_CP058409
• Organism: Trichlorobacter lovleyi strain IAE

Toxin (Protein)

• Gene name: tad
• Uniprot ID: B3E6M8
• Locus tag: FY034_RS04860
• Protein ID: WP_012469202.1
• Coordinates: 1073687..1074052 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: FY034_RS04855
• Protein ID: WP_265554184.1
• Coordinates: 1073351..1073680 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY034_RS04820 (FY034_04825)	1068681..1069196	-	516	WP_265554171.1	hypothetical protein	-
FY034_RS04825 (FY034_04830)	1069231..1070577	-	1347	WP_265554172.1	replicative DNA helicase	-
FY034_RS04830 (FY034_04835)	1070564..1070791	-	228	WP_265554174.1	hypothetical protein	-
FY034_RS04835 (FY034_04840)	1070848..1071519	-	672	WP_265554176.1	hypothetical protein	-
FY034_RS04840 (FY034_04845)	1071808..1072200	-	393	WP_265554178.1	hypothetical protein	-
FY034_RS04845 (FY034_04850)	1072197..1072394	-	198	WP_265554179.1	helix-turn-helix domain-containing protein	-
FY034_RS04850 (FY034_04855)	1072501..1073130	+	630	WP_265554181.1	helix-turn-helix transcriptional regulator	-
FY034_RS04855 (FY034_04860)	1073351..1073680	-	330	WP_265554184.1	helix-turn-helix transcriptional regulator	Antitoxin
FY034_RS04860 (FY034_04865)	1073687..1074052	-	366	WP_012469202.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FY034_RS04865 (FY034_04870)	1074104..1074658	-	555	WP_012469203.1	recombinase family protein	-
FY034_RS04870 (FY034_04875)	1074921..1075265	-	345	WP_012469204.1	helix-turn-helix transcriptional regulator	-
FY034_RS04875 (FY034_04880)	1075234..1075512	-	279	WP_265554188.1	cytotoxic translational repressor of toxin-antitoxin stability system	-
FY034_RS04880 (FY034_04885)	1075562..1076824	-	1263	WP_265554189.1	integrase arm-type DNA-binding domain-containing protein	-
FY034_RS04895 (FY034_04900)	1077260..1077991	-	732	WP_265554190.1	SPOR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (17-110)

Antitoxin

• HigA2-like, helix-turn-helix domain (14-93)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13583.75 Da
• Isoelectric Point: 10.1231

>T166740 WP_012469202.1 NZ_CP058409:c1074052-1073687 [Trichlorobacter lovleyi]
MNNKPTKPLEWIASSLKDLKEMPEDVRRFFGVALFMAQAGGKHPDAKPLKGFSGAGVLEIVEDHDGDTYRAVYTVRFADV
VYVLHVFQKKSKTGIATPQAEIEKIKTRLKMAEELHRGKGR

Nucleotide

• Length: 366 bp

>T166740 NZ_CP074418:26613-26954 [Vibrio parahaemolyticus]
ATGACGTATGCAGTACCAGAGAAAGGCGATGTAGTAGTAATGAGTTTTAATCCGCAAAGCGGACACGAACAAGCGGGAGA
CAGTCGGCCTGGGCTGGTCATTTCCCCGAAAGAGTTTAACCAAGCAACTGGCTTTGCTCTGGTATGCCCCATAACCAACC
AGTCAAAAGGATATCCGTTTGAAGTTGAAATAACCGGAAGCCAAAAAACAACGGGTGTGGTGCTGGCTGACCAAGTGAAG
TCCTTGGATTGGCGCGCGCGTCGCGCTCGTGTGGTGGACTCCGTTTCAAACGAAACACTGGGGACTGTGCGGGATTATGT
CACAGCGATTGCTAATGGCTGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12270.39 Da
• Isoelectric Point: 10.3969

>AT166740 WP_265554184.1 NZ_CP058409:c1073680-1073351 [Trichlorobacter lovleyi]
MKEEIELYHSSGNVFADLELPDAEEMQAKALLSIQIHDIIKRRHLTQAQAAELLGIDQPKVSALIRGRLKGFSMERLFHF
LNLLGRDVKIVIKPKARSRQLGSLRVAAA

Nucleotide

• Length: 330 bp

>AT166740 NZ_CP074418:26386-26616 [Vibrio parahaemolyticus]
ATGTCACAAACAATAGCTAAGTGGGGCCACAGCGCAGCTGTGCGTATACCTTCTAAGGTATTGAAAAATATGGATATGGC
GGTGGGTGACAAAGTGGAGGTTAAAGTGTTCAATCGACAAATTATCATTGAACCTGCAAAACCAACACTCGCCCAGATTT
TGAGTCAGATCACTGATGAAAACCGCCATGATGAAGTAATCACCGAAACTATGGGTAATGAATTGTTATGA

Structures

Toxin

• AlphaFold DB: B3E6M8