Detailed information of TA system TA166734

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4955922..4957603
• Replicon: chromosome
• Accession: NZ_CP058361
• Organism: Klebsiella pneumoniae strain KP77

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A486RE08
• Locus tag: HYD36_RS24285
• Protein ID: WP_023287018.1
• Coordinates: 4955922..4956839 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A486RD25
• Locus tag: HYD36_RS24290
• Protein ID: WP_023287017.1
• Coordinates: 4956845..4957603 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYD36_RS24265 (4951228)	4951228..4952748	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
HYD36_RS24270 (4952745)	4952745..4953743	+	999	WP_002885172.1	ribose ABC transporter permease	-
HYD36_RS24275 (4953774)	4953774..4954715	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
HYD36_RS24280 (4954790)	4954790..4955797	+	1008	WP_023287019.1	carbohydrate kinase family protein	-
HYD36_RS24285 (4955922)	4955922..4956839	-	918	WP_023287018.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HYD36_RS24290 (4956845)	4956845..4957603	-	759	WP_023287017.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
HYD36_RS24295 (4957689)	4957689..4958417	-	729	WP_004177810.1	response regulator transcription factor	-
HYD36_RS24300 (4958690)	4958690..4960837	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
HYD36_RS24305 (4961067)	4961067..4961753	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34587.04 Da
• Isoelectric Point: 5.7772

>T166734 WP_023287018.1 NZ_CP058361:c4956839-4955922 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIGVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T166734 NZ_CP074412:c5983625-5983347 [Pseudomonas viridiflava]
ATGATTGTGAGTTTCAAATGCGGTGATACGCGAGGACTTTTTCAGCATGGCAAAACCCGGCTTTGGCCTGCTTTGAAGGC
GGTTGCAGAGCGAAAGCTCGCAATGCTGGACGCGGCGGTCCTGCTGTCGGATCTTCGATCCCCACCGGGCAACCGGCTTG
AAATACTTGATGGTGATCGTCGCGGCCAGCACAGCATACGTATCAATGCCCAGTTTCGAATTTGCTTCGTTTGGGGAGAG
AACGGCCCTGAGAACGTTGAAATTGTCGATTACCACTGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28534.90 Da
• Isoelectric Point: 10.0870

>AT166734 WP_023287017.1 NZ_CP058361:c4957603-4956845 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVVSGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT166734 NZ_CP074412:c5983337-5983032 [Pseudomonas viridiflava]
ATGACAAAAAATGGAATGCGCCCCGTCCATCCCGGCGAGGTTCTTAAAGAAGAGTACCTTGAGCCCATGGGGCTAACCGC
CGCTGCCTTGGCTAGGGCGCTGAATGTATCAACACCGACAGTCAATGACATCGTTTTACAGCGAAGGGGTGTGAGCGCGG
ATGTCGCGCTGCGTCTGGGCGTATGCCTTGAGACGAGCCCCGAGTTCTGGCTGAACCTGCAGCTGACTTATGACTTGCGC
AAGGCAGAAATCGAGAAGGGTGCACAGATTCGCGATCAGGTCAGGCGTCTGGCCCGCTGTGCCTGA

Structures

Toxin

• AlphaFold DB: A0A486RE08

Antitoxin

• AlphaFold DB: A0A486RD25