Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2624523..2626111 Replicon chromosome
Accession NZ_CP058361
Organism Klebsiella pneumoniae strain KP77

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag HYD36_RS12780 Protein ID WP_004199851.1
Coordinates 2624523..2625845 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag HYD36_RS12785 Protein ID WP_002904790.1
Coordinates 2625845..2626111 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYD36_RS12765 (2619588) 2619588..2622089 + 2502 WP_023286424.1 fimbria/pilus outer membrane usher protein -
HYD36_RS12770 (2622077) 2622077..2623081 + 1005 WP_023286423.1 fimbrial protein -
HYD36_RS12775 (2623214) 2623214..2624506 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
HYD36_RS12780 (2624523) 2624523..2625845 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
HYD36_RS12785 (2625845) 2625845..2626111 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HYD36_RS12790 (2626376) 2626376..2626702 - 327 WP_002904788.1 hydroxyisourate hydrolase -
HYD36_RS12795 (2626699) 2626699..2627199 - 501 WP_023286422.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HYD36_RS12800 (2627177) 2627177..2628556 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
HYD36_RS12805 (2628902) 2628902..2630056 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
HYD36_RS12810 (2630037) 2630037..2630960 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T166730 WP_004199851.1 NZ_CP058361:c2625845-2624523 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T166730 NZ_CP074411:c5568512-5568222 [Pseudomonas syringae]
ATGACCTATAACCTCGAATTCGATGCGCGGGCTCTAAAGGAATGGCACAAATTAGGGGATACCGTGCGTCAGCAGCTCAA
GAAAAAGCTGGCTACGATTCTGGTTGCTCCGCGTGTTGAAGCCAATCGTCTGCATGCATTGCCTGACTGCTACAAAATCA
AACTGCGCAGTAGCGGCTATCGGCTGGTTTATCAGGTTATTGACCAAGAGGTTGTGGTCTTCGTGGTTGCTGTGGACAAG
CGTGAGCGAGAGGAGGTTTACTGTAAAGCGGCTGATCGGTTGGGTAGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT166730 WP_002904790.1 NZ_CP058361:c2626111-2625845 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT166730 NZ_CP074411:c5568741-5568502 [Pseudomonas syringae]
ATGGCGTCTATCAACGTTCGTATCGACGACGATCTCAAAGCGCGTGCTTACCTCGAGCTGGAAAAGCTTGGCGTCACCCC
CTCGGAGTTGCTGCGCCAAACCCTGCAGTATGTAGCTGAGCGTGGCCAGCTGCCCTTCAAGACGGTTCTGATGACAGAGG
AAGACGAAGCGCTGTTGGCAACTGTGCGCGAGCGCCTTGCAGCTCCGCAGCGGGTCAAGGTTTCACTGGATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References