Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4880045..4880561 Replicon chromosome
Accession NZ_CP058358
Organism Klebsiella pneumoniae strain KP486

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag HYD35_RS23925 Protein ID WP_004178374.1
Coordinates 4880045..4880329 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HYD35_RS23930 Protein ID WP_002886901.1
Coordinates 4880319..4880561 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYD35_RS23900 (4875441) 4875441..4875704 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
HYD35_RS23905 (4875834) 4875834..4876007 + 174 WP_032414379.1 hypothetical protein -
HYD35_RS23910 (4876010) 4876010..4876753 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HYD35_RS23915 (4877110) 4877110..4879248 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HYD35_RS23920 (4879577) 4879577..4880041 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HYD35_RS23925 (4880045) 4880045..4880329 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HYD35_RS23930 (4880319) 4880319..4880561 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HYD35_RS23935 (4880639) 4880639..4882549 - 1911 WP_009486549.1 PRD domain-containing protein -
HYD35_RS23940 (4882572) 4882572..4883726 - 1155 WP_023287050.1 lactonase family protein -
HYD35_RS23945 (4883793) 4883793..4884533 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T166714 WP_004178374.1 NZ_CP058358:c4880329-4880045 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T166714 NZ_CP074407:3651781-3652068 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT166714 WP_002886901.1 NZ_CP058358:c4880561-4880319 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT166714 NZ_CP074407:3651542-3651781 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References