Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1366766..1367423 Replicon chromosome
Accession NZ_CP058358
Organism Klebsiella pneumoniae strain KP486

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HYD35_RS06720 Protein ID WP_002916310.1
Coordinates 1366766..1367176 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HYD35_RS06725 Protein ID WP_002916312.1
Coordinates 1367157..1367423 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYD35_RS06700 (1362766) 1362766..1364499 - 1734 WP_023286863.1 single-stranded-DNA-specific exonuclease RecJ -
HYD35_RS06705 (1364505) 1364505..1365218 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HYD35_RS06710 (1365241) 1365241..1366137 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HYD35_RS06715 (1366238) 1366238..1366759 + 522 WP_002916308.1 flavodoxin FldB -
HYD35_RS06720 (1366766) 1366766..1367176 - 411 WP_002916310.1 protein YgfX Toxin
HYD35_RS06725 (1367157) 1367157..1367423 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HYD35_RS06730 (1367669) 1367669..1368652 + 984 WP_210147408.1 tRNA-modifying protein YgfZ -
HYD35_RS06735 (1368751) 1368751..1369410 - 660 WP_002916317.1 hemolysin III family protein -
HYD35_RS06740 (1369574) 1369574..1369885 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
HYD35_RS06745 (1369935) 1369935..1370663 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HYD35_RS06750 (1370782) 1370782..1372215 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T166701 WP_002916310.1 NZ_CP058358:c1367176-1366766 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T166701 NZ_CP074407:10718-11260 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCAGG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT166701 WP_002916312.1 NZ_CP058358:c1367423-1367157 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT166701 NZ_CP074407:10423-10734 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAACTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References