Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2427547..2428118 Replicon chromosome
Accession NZ_CP058354
Organism Bradyrhizobium japonicum strain 5038

Toxin (Protein)


Gene name mazF Uniprot ID A0A845IZB5
Locus tag HXT67_RS10885 Protein ID WP_014497460.1
Coordinates 2427547..2427900 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HXT67_RS10890 Protein ID WP_080583987.1
Coordinates 2427897..2428118 (-) Length 74 a.a.

Genomic Context

HXT67_RS10860HXT67_RS10865HXT67_RS10870HXT67_RS10880HXT67_RS10895HXT67_RS10900HXT67_RS10875HXT67_RS10885HXT67_RS10890
Location: 2423764..2424000 (237 bp)
Type: Others
Protein ID: WP_014497465.1
Location: 2424099..2424344 (246 bp)
Type: Others
Protein ID: WP_014497464.1
Location: 2424459..2425622 (1164 bp)
Type: Others
Protein ID: WP_014497463.1
Location: 2426150..2427481 (1332 bp)
Type: Others
Protein ID: WP_014497461.1
Location: 2428295..2429401 (1107 bp)
Type: Others
Protein ID: WP_028170414.1
Location: 2429635..2432772 (3138 bp)
Type: Others
Protein ID: WP_014497458.1
Location: 2425641..2426069 (429 bp)
Type: Others
Protein ID: WP_014497462.1
Location: 2427547..2427900 (354 bp)
Type: Toxin
Protein ID: WP_014497460.1
Location: 2427897..2428118 (222 bp)
Type: Antitoxin
Protein ID: WP_080583987.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HXT67_RS108602423764..2424000+237WP_014497465.1hypothetical protein-
HXT67_RS108652424099..2424344+246WP_014497464.1hypothetical protein-
HXT67_RS108702424459..2425622+1164WP_014497463.1winged helix-turn-helix domain-containing protein-
HXT67_RS108752425641..2426069-429WP_014497462.1DUF2809 domain-containing protein-
HXT67_RS108802426150..2427481+1332WP_014497461.1MFS transporter-
HXT67_RS108852427547..2427900-354WP_014497460.1type II toxin-antitoxin system PemK/MazF family toxinToxin
HXT67_RS108902427897..2428118-222WP_080583987.1antitoxin MazE family proteinAntitoxin
HXT67_RS108952428295..2429401+1107WP_028170414.1efflux RND transporter periplasmic adaptor subunit-
HXT67_RS109002429635..2432772+3138WP_014497458.1efflux RND transporter permease subunit-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-104)

Antitoxin

Antitoxin MazE-like

(12-73)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 12687.49 Da        Isoelectric Point: 6.3275

>T166668 WP_014497460.1 NZ_CP058354:c2427900-2427547 [Bradyrhizobium japonicum]
MKRGEIWTVAGGKDYAGKPRPVVIVQDDSFDATNSITVCAFTTDETEAPLFRLKVEPNDNNGLRVPSRLMVDKITTVPKA
KVGTLVGRLDDDDLLRLNRAVLVFLGLAGSQRSASAD

Download         Length: 354 bp

>T166668 NZ_CP074366:3821190-3821468 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8248.25 Da        Isoelectric Point: 10.4527

>AT166668 WP_080583987.1 NZ_CP058354:c2428118-2427897 [Bradyrhizobium japonicum]
MSPSKPKPSRLKVQAHRDRLRAQGLRPIQIWVPDIRSPSFRSEAHRQSLAVATSVHASEDQGFIDAVSDWTDE

Download         Length: 222 bp

>AT166668 NZ_CP074366:3820927-3821187 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A845IZB5

Antitoxin

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Source
ID
Structure
No matching records found

References