Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4144646..4145315 Replicon chromosome
Accession NZ_CP058353
Organism Serratia marcescens strain ESE2014

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HW877_RS19920 Protein ID WP_016929976.1
Coordinates 4144646..4145068 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag HW877_RS19925 Protein ID WP_004931679.1
Coordinates 4145049..4145315 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW877_RS19900 (HW877_19885) 4140532..4141050 + 519 WP_004931683.1 flavodoxin FldB -
HW877_RS19905 (HW877_19890) 4141088..4142452 - 1365 WP_244757788.1 cell envelope integrity protein CreD -
HW877_RS19910 (HW877_19895) 4142533..4143951 - 1419 WP_033639474.1 two-component system sensor histidine kinase CreC -
HW877_RS19915 (HW877_19900) 4143948..4144646 - 699 WP_048795299.1 two-component system response regulator CreB -
HW877_RS19920 (HW877_19905) 4144646..4145068 - 423 WP_016929976.1 protein YgfX Toxin
HW877_RS19925 (HW877_19910) 4145049..4145315 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
HW877_RS19930 (HW877_19915) 4145636..4146628 + 993 WP_244757789.1 tRNA-modifying protein YgfZ -
HW877_RS19935 (HW877_19920) 4146667..4147164 - 498 WP_033639468.1 DUF2165 domain-containing protein -
HW877_RS19940 (HW877_19925) 4147315..4147989 - 675 WP_033639467.1 hemolysin III family protein -
HW877_RS19945 (HW877_19930) 4148173..4148781 + 609 WP_028127691.1 HD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16501.62 Da        Isoelectric Point: 11.2159

>T166666 WP_016929976.1 NZ_CP058353:c4145068-4144646 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLHPPAGNGEEP

Download         Length: 423 bp

>T166666 NZ_CP074366:3564805-3565023 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT166666 WP_004931679.1 NZ_CP058353:c4145315-4145049 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT166666 NZ_CP074366:3564405-3564779 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References