Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1549831..1550379 Replicon chromosome
Accession NZ_CP058353
Organism Serratia marcescens strain ESE2014

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag HW877_RS07415 Protein ID WP_028127948.1
Coordinates 1550077..1550379 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag HW877_RS07410 Protein ID WP_025302143.1
Coordinates 1549831..1550067 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW877_RS07395 (HW877_07410) 1546317..1547852 + 1536 WP_016928459.1 glutathione ABC transporter substrate-binding protein GsiB -
HW877_RS07400 (HW877_07415) 1547905..1548825 + 921 WP_016928458.1 glutathione ABC transporter permease GsiC -
HW877_RS07405 (HW877_07420) 1548835..1549743 + 909 WP_016928457.1 glutathione ABC transporter permease GsiD -
HW877_RS07410 (HW877_07425) 1549831..1550067 + 237 WP_025302143.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HW877_RS07415 (HW877_07430) 1550077..1550379 + 303 WP_028127948.1 CcdB family protein Toxin
HW877_RS07420 (HW877_07435) 1550416..1551258 - 843 WP_244758055.1 S-formylglutathione hydrolase -
HW877_RS07425 (HW877_07440) 1551273..1552397 - 1125 WP_016928454.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
HW877_RS07430 (HW877_07445) 1552427..1553347 - 921 WP_079449477.1 LysR family transcriptional regulator -
HW877_RS07435 (HW877_07450) 1553453..1554610 + 1158 WP_244758056.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-99)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11210.98 Da        Isoelectric Point: 5.0196

>T166655 WP_028127948.1 NZ_CP058353:1550077-1550379 [Serratia marcescens]
ITVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGKAVG
NVNEHRNQIKAAIDFLIDGF

Download         Length: 303 bp

>T166655 NZ_CP074366:1404977-1405375 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8967.04 Da        Isoelectric Point: 5.0807

>AT166655 WP_025302143.1 NZ_CP058353:1549831-1550067 [Serratia marcescens]
MANSNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp

>AT166655 NZ_CP074366:1404750-1404977 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References