Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-YefM |
| Location | 1420890..1421457 | Replicon | chromosome |
| Accession | NZ_CP058353 | ||
| Organism | Serratia marcescens strain ESE2014 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | HW877_RS06745 | Protein ID | WP_072270879.1 |
| Coordinates | 1420890..1421195 (-) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A8B4G8D1 |
| Locus tag | HW877_RS06750 | Protein ID | WP_016928576.1 |
| Coordinates | 1421197..1421457 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HW877_RS06710 (HW877_06725) | 1416538..1417614 | + | 1077 | WP_048796603.1 | urea ABC transporter permease subunit UrtC | - |
| HW877_RS06715 (HW877_06730) | 1417611..1418417 | + | 807 | WP_015377102.1 | urea ABC transporter ATP-binding protein UrtD | - |
| HW877_RS06720 (HW877_06735) | 1418430..1419128 | + | 699 | WP_089184363.1 | urea ABC transporter ATP-binding subunit UrtE | - |
| HW877_RS06725 | 1419250..1419435 | - | 186 | WP_232065802.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HW877_RS06730 (HW877_06745) | 1419420..1419683 | - | 264 | WP_004939442.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| HW877_RS06735 (HW877_06750) | 1419818..1420330 | + | 513 | WP_033640967.1 | DUF2165 family protein | - |
| HW877_RS06740 (HW877_06755) | 1420353..1420865 | - | 513 | WP_033640966.1 | GNAT family N-acetyltransferase | - |
| HW877_RS06745 (HW877_06760) | 1420890..1421195 | - | 306 | WP_072270879.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HW877_RS06750 (HW877_06765) | 1421197..1421457 | - | 261 | WP_016928576.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HW877_RS06755 (HW877_06770) | 1421526..1422761 | - | 1236 | WP_033640964.1 | FAD-dependent oxidoreductase | - |
| HW877_RS06760 (HW877_06775) | 1422838..1423407 | - | 570 | WP_079450950.1 | DUF4865 family protein | - |
| HW877_RS06765 (HW877_06780) | 1423513..1424382 | + | 870 | WP_033640963.1 | LysR substrate-binding domain-containing protein | - |
| HW877_RS06770 (HW877_06785) | 1424379..1425224 | - | 846 | WP_033640962.1 | 3-mercaptopyruvate sulfurtransferase | - |
| HW877_RS06775 (HW877_06790) | 1425331..1425756 | + | 426 | WP_033641463.1 | NUDIX hydrolase | - |
| HW877_RS06780 (HW877_06795) | 1425764..1426429 | - | 666 | WP_244758038.1 | epimerase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11927.69 Da Isoelectric Point: 9.5902
>T166654 WP_072270879.1 NZ_CP058353:c1421195-1420890 [Serratia marcescens]
MPAFRLTPQAQQDLLAIRHFTIEHWGQAQSRRYLEQLREVMHHLADMPEAGKAHFHDLGEEIRSFPYASHRIYYRSRPAG
ITVLAILHQAMVPHRHLEQRL
MPAFRLTPQAQQDLLAIRHFTIEHWGQAQSRRYLEQLREVMHHLADMPEAGKAHFHDLGEEIRSFPYASHRIYYRSRPAG
ITVLAILHQAMVPHRHLEQRL
Download Length: 306 bp
>T166654 NZ_CP074366:1072520-1072855 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 87 a.a. Molecular weight: 9442.59 Da Isoelectric Point: 4.1964
>AT166654 WP_016928576.1 NZ_CP058353:c1421457-1421197 [Serratia marcescens]
MYALTANEAKTQFGDLLLKAQREPVQINRNGKPVAVVMSVEDYQALEDLKLSALQQKIAQATAEEDAGKAVDGDAFFNRL
LTDETD
MYALTANEAKTQFGDLLLKAQREPVQINRNGKPVAVVMSVEDYQALEDLKLSALQQKIAQATAEEDAGKAVDGDAFFNRL
LTDETD
Download Length: 261 bp
>AT166654 NZ_CP074366:1072272-1072520 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|