Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1066510..1067131 Replicon chromosome
Accession NZ_CP058353
Organism Serratia marcescens strain ESE2014

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag HW877_RS04975 Protein ID WP_004940313.1
Coordinates 1066510..1066713 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag HW877_RS04980 Protein ID WP_004940312.1
Coordinates 1066763..1067131 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW877_RS04945 (HW877_04960) 1062210..1062548 + 339 WP_004940327.1 P-II family nitrogen regulator -
HW877_RS04950 (HW877_04965) 1062584..1063870 + 1287 WP_004940322.1 ammonium transporter AmtB -
HW877_RS04955 (HW877_04970) 1063961..1064824 - 864 WP_016928847.1 acyl-CoA thioesterase II -
HW877_RS04960 (HW877_04975) 1065055..1065546 + 492 WP_016928846.1 YbaY family lipoprotein -
HW877_RS04965 (HW877_04980) 1065611..1065925 - 315 WP_004940317.1 MGMT family protein -
HW877_RS04975 (HW877_04990) 1066510..1066713 - 204 WP_004940313.1 HHA domain-containing protein Toxin
HW877_RS04980 (HW877_04995) 1066763..1067131 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
HW877_RS04985 (HW877_05000) 1067290..1067643 - 354 WP_048795900.1 hypothetical protein -
HW877_RS04990 (HW877_05005) 1068048..1068761 + 714 WP_115116167.1 ABC transporter ATP-binding protein -
HW877_RS04995 (HW877_05010) 1068758..1069615 + 858 WP_004940309.1 metal ABC transporter permease -
HW877_RS05000 (HW877_05015) 1069641..1070519 + 879 WP_244757982.1 metal ABC transporter substrate-binding protein -
HW877_RS05005 (HW877_05020) 1070627..1070767 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
HW877_RS05010 (HW877_05025) 1070780..1071034 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T166653 WP_004940313.1 NZ_CP058353:c1066713-1066510 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T166653 NZ_CP074366:936185-936592 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT166653 WP_004940312.1 NZ_CP058353:c1067131-1066763 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT166653 NZ_CP074366:935938-936204 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References