Detailed information of TA system TA166652

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 105712..106247
• Replicon: chromosome
• Accession: NZ_CP058353
• Organism: Serratia marcescens strain ESE2014

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5C7D971
• Locus tag: HW877_RS00490
• Protein ID: WP_033636570.1
• Coordinates: 105972..106247 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8G2GBD7
• Locus tag: HW877_RS00485
• Protein ID: WP_033639076.1
• Coordinates: 105712..105972 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HW877_RS00465 (HW877_00465)	101038..101688	+	651	WP_033639079.1	DcrB-related protein	-
HW877_RS00470 (HW877_00470)	101724..102329	+	606	WP_004934025.1	glutathione S-transferase	-
HW877_RS00475 (HW877_00475)	102397..103791	+	1395	WP_060444908.1	L-seryl-tRNA(Sec) selenium transferase	-
HW877_RS00480 (HW877_00480)	103788..105629	+	1842	WP_244757860.1	selenocysteine-specific translation elongation factor	-
HW877_RS00485 (HW877_00485)	105712..105972	+	261	WP_033639076.1	ribbon-helix-helix domain-containing protein	Antitoxin
HW877_RS00490 (HW877_00490)	105972..106247	+	276	WP_033636570.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HW877_RS00495 (HW877_00495)	106259..107170	-	912	WP_033639075.1	LysR family transcriptional regulator	-
HW877_RS00500 (HW877_00500)	107292..107918	+	627	WP_244757861.1	LysE family translocator	-
HW877_RS00505 (HW877_00505)	107972..109219	-	1248	WP_028127797.1	MFS transporter	-
HW877_RS00510 (HW877_00510)	109437..110429	+	993	WP_197755631.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10578.32 Da
• Isoelectric Point: 10.3377

>T166652 WP_033636570.1 NZ_CP058353:105972-106247 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Nucleotide

• Length: 276 bp

>T166652 NZ_CP074366:c601010-600546 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9682.01 Da
• Isoelectric Point: 4.5317

>AT166652 WP_033639076.1 NZ_CP058353:105712-105972 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALAAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDE
PLPVPR

Nucleotide

• Length: 261 bp

>AT166652 NZ_CP074366:c601345-601010 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: A0A5C7D971