Detailed information of TA system TA166644

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 1422622..1423246
• Replicon: chromosome
• Accession: NZ_CP058350
• Organism: Rhizobium sp. ADMK78

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FE840_RS06735
• Protein ID: WP_138285603.1
• Coordinates: 1422622..1423026 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FE840_RS06740
• Protein ID: WP_138285602.1
• Coordinates: 1423016..1423246 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FE840_RS06715	1418296..1419333	+	1038	WP_138285607.1	dihydroorotase	-
FE840_RS06720	1419593..1420771	+	1179	WP_138285606.1	GGDEF domain-containing protein	-
FE840_RS06725	1420873..1421562	+	690	WP_138285605.1	orotate phosphoribosyltransferase	-
FE840_RS06730	1421641..1422567	+	927	WP_138285604.1	carbohydrate kinase	-
FE840_RS06735	1422622..1423026	-	405	WP_138285603.1	PIN domain-containing protein	Toxin
FE840_RS06740	1423016..1423246	-	231	WP_138285602.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FE840_RS06745	1423331..1424959	-	1629	WP_138285601.1	glucose-6-phosphate isomerase	-
FE840_RS06750	1425059..1426765	-	1707	WP_138285600.1	long-chain fatty acid--CoA ligase	-
FE840_RS06755	1426990..1427382	+	393	WP_138285599.1	PRC-barrel domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-114)

Antitoxin

• SpoVT-AbrB domain (5-33)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14830.12 Da
• Isoelectric Point: 4.4493

>T166644 WP_138285603.1 NZ_CP058350:c1423026-1422622 [Rhizobium sp. ADMK78]
MGGRFVDTNVLLNLASGDAQRADRAEAVIAEGGIISVQVLNEIANVLRRKMRMPWPDTHLFLDMIRALLTVEPVTWETHE
TGLRIAERYGLSIYDAMIVSAALMAGCDTLMSEDMQDGLVIDDRLRIVNPFGQA

Nucleotide

• Length: 405 bp

>T166644 NZ_CP074365:c1167760-1167464 [Xanthomonas translucens]
GTGATCGAACTCAAACAGACCGAGACGTTCCGCAAGTGGCGCACGAAGCTGAAGGACGAGCGCGCTCGCACTGCGATTGC
CTTGCGCTTGACCCGACTTGCCTATGGCCATGCCGGCGATACGGAAGCTGTCGGGCAAGGCATCAGCGAGCTGCGTATCC
ACCATGGCCCCGGATATCGGGTGTATTTCCAGCGGCGCGGCGACACGATCATCGTCTTGCTCTGCGGTGGCGACAAAAGC
ACGCAGGCAAAGGACATCAAGACAGCCAAACGGCTTGCCGACGAATGGAGCGAATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8778.06 Da
• Isoelectric Point: 8.6354

>AT166644 WP_138285602.1 NZ_CP058350:c1423246-1423016 [Rhizobium sp. ADMK78]
MQIAKWGNSLAVRLPASVVEALKLKEGDDIEIRAADWRELDVARKPTPEDLLERLRAFRGRLPPDFKFDRYEANGR

Nucleotide

• Length: 231 bp

>AT166644 NZ_CP074365:c1167461-1167168 [Xanthomonas translucens]
ATGACCGAAAACCTGACCACCTACGATCCTGCCGAGGATCTGAACTCCGACCAGGCGATTGCCGATTTCATGGCGGGCGC
CTTTGCGACCAACGACACCGGCTTCATCGCCCATGCCCTCGGCATCGTCGCCCGTGCCAAGGGCATGACCCAGATCGCAC
GACAAACCGGCCTGTCCCGGGAGCAGCTCTACCGCTCCTTCAGCGAGGACGGAAATCCGACGCTGCGCACTACCCTGGCC
GTCATGAAGGCGCTCGGGATCGAACTGACGGCCAAAGCCGCCGTCACGCATTGA