Detailed information of TA system TA166641

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 32222..32823
• Replicon: chromosome
• Accession: NZ_CP058350
• Organism: Rhizobium sp. ADMK78

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FE840_RS00185
• Protein ID: WP_138287921.1
• Coordinates: 32222..32404 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FE840_RS00190
• Protein ID: WP_138287922.1
• Coordinates: 32425..32823 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FE840_RS00165	28297..30078	+	1782	Protein_32	M3 family oligoendopeptidase	-
FE840_RS00170	30101..31264	+	1164	WP_138287918.1	aminodeoxychorismate synthase component I	-
FE840_RS00175	31249..31878	+	630	WP_138287919.1	aminotransferase class IV family protein	-
FE840_RS00180	31878..32162	+	285	WP_138287920.1	GTP cyclohydrolase	-
FE840_RS00185	32222..32404	+	183	WP_138287921.1	type II toxin-antitoxin system HicA family toxin	Toxin
FE840_RS00190	32425..32823	+	399	WP_138287922.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FE840_RS00195	32841..33701	+	861	WP_138288021.1	DUF3445 domain-containing protein	-
FE840_RS00200	33870..35312	+	1443	WP_138287923.1	homospermidine synthase	-
FE840_RS00205	35507..35869	+	363	WP_138287924.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6629.83 Da
• Isoelectric Point: 11.0889

>T166641 WP_138287921.1 NZ_CP058350:32222-32404 [Rhizobium sp. ADMK78]
MEKDSRKIVQRLKAEGYELVSVSGSHHKLRKGGKTIIVPHPKKDLPLGTARAIAKQAGWI

Nucleotide

• Length: 183 bp

>T166641 NZ_CP074364:c4014105-4013911 [Xanthomonas translucens pv. cerealis]
ATGCCCCCGAAAATCCGCGACGTGCTGCAACAACTCAGGGACGCAGGCTGGCAGCAAGTCGGCCAGACCGGCAGCCACCG
CCAGTTCAAGCATCCTGTCTACCCAGGCCGCGTGACAGTGGCCGGCAAGCCGAGCGATGATGTGGCTCCCGGCACCCTGA
ACAGCATCCTTAAACAGGCCGGCCTGAAGAGGTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14503.49 Da
• Isoelectric Point: 4.7560

>AT166641 WP_138287922.1 NZ_CP058350:32425-32823 [Rhizobium sp. ADMK78]
MRYYVALVYKDPESAYGISFPDLPSVFSAADRDEDLVIKAIEALRLWAEDEALPLPSSHQAILARHDIQAELASGAFLIR
VPLIEDDTRTVRANITMDAGTLAAIDQAAKQRGLTRSAFLASCARKEIERSA

Nucleotide

• Length: 399 bp

>AT166641 NZ_CP074364:c4013905-4013693 [Xanthomonas translucens pv. cerealis]
ATGCGCTACGCCGTTGTCATTGAGCAAGCGGGTAACAACTACTCCGCCTATGTGCCGGATCTGCCGGGATGTGTGGCGAC
AGGTGCGACGACTGCGGAGGTGGAAGGTTTGATCCGCGAGGCGATCGAGTTGCATCTGGCGGGTATGCGCGAGGATGGAG
AAGTGATTCCGCTGCCGTCGAGCCAAGTTGAGTATGTGAATGTGGCAGCGTGA