Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PumA-relB/upstrm_HI1419-dnstrm_HI1420 |
| Location | 834713..835335 | Replicon | chromosome |
| Accession | NZ_CP058347 | ||
| Organism | Treponema denticola strain OKA3 | ||
Toxin (Protein)
| Gene name | PumA | Uniprot ID | - |
| Locus tag | E4N90_RS03940 | Protein ID | WP_253703252.1 |
| Coordinates | 834713..835021 (+) | Length | 103 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | E4N90_RS03945 | Protein ID | WP_253703253.1 |
| Coordinates | 835018..835335 (+) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E4N90_RS03895 (E4N90_03880) | 830035..831129 | - | 1095 | WP_253703241.1 | Clp protease ClpP | - |
| E4N90_RS03900 (E4N90_03885) | 831130..831555 | - | 426 | WP_253703243.1 | hypothetical protein | - |
| E4N90_RS03905 (E4N90_03890) | 831637..831945 | - | 309 | WP_253703245.1 | NadS family protein | - |
| E4N90_RS03910 (E4N90_03895) | 831955..832263 | - | 309 | WP_253703686.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| E4N90_RS03915 (E4N90_03900) | 832366..832572 | - | 207 | WP_253703247.1 | helix-turn-helix domain-containing protein | - |
| E4N90_RS03920 (E4N90_03905) | 832982..833332 | - | 351 | WP_253703248.1 | hypothetical protein | - |
| E4N90_RS03925 (E4N90_03910) | 833313..833675 | - | 363 | WP_253703249.1 | hypothetical protein | - |
| E4N90_RS03930 (E4N90_03915) | 834010..834318 | + | 309 | WP_253703250.1 | BrnT family toxin | - |
| E4N90_RS03935 (E4N90_03920) | 834287..834601 | + | 315 | WP_253703251.1 | BrnA antitoxin family protein | - |
| E4N90_RS03940 (E4N90_03925) | 834713..835021 | + | 309 | WP_253703252.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| E4N90_RS03945 (E4N90_03930) | 835018..835335 | + | 318 | WP_253703253.1 | putative addiction module antidote protein | Antitoxin |
| E4N90_RS03950 (E4N90_03935) | 835337..835621 | + | 285 | WP_016512045.1 | putative addiction module antidote protein | - |
| E4N90_RS03955 (E4N90_03940) | 835668..835865 | - | 198 | WP_253703256.1 | DNA-binding protein | - |
| E4N90_RS03960 (E4N90_03945) | 836320..836637 | - | 318 | WP_253703257.1 | hypothetical protein | - |
| E4N90_RS03965 (E4N90_03950) | 836648..836959 | - | 312 | WP_253703259.1 | DUF4406 domain-containing protein | - |
| E4N90_RS03970 (E4N90_03955) | 837022..837240 | - | 219 | WP_253703261.1 | hypothetical protein | - |
| E4N90_RS03975 (E4N90_03960) | 837215..837493 | - | 279 | WP_253703263.1 | hypothetical protein | - |
| E4N90_RS03980 (E4N90_03965) | 837496..838038 | - | 543 | WP_253703264.1 | hypothetical protein | - |
| E4N90_RS03985 (E4N90_03970) | 838083..838304 | - | 222 | WP_002674781.1 | hypothetical protein | - |
| E4N90_RS03990 (E4N90_03975) | 838327..838815 | - | 489 | WP_253703267.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 803667..856477 | 52810 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 103 a.a. Molecular weight: 11976.99 Da Isoelectric Point: 10.4734
>T166633 WP_253703252.1 NZ_CP058347:834713-835021 [Treponema denticola]
MRTIKKTEVFNTWLSKLKDEKGKAKITDRIMRLKRGNKGDYRTIDKDIYELRIHFGPGYRIYCTDRNNEIILLLIAGNKS
TQSKDIKKAQEMIKLLEQGDSK
MRTIKKTEVFNTWLSKLKDEKGKAKITDRIMRLKRGNKGDYRTIDKDIYELRIHFGPGYRIYCTDRNNEIILLLIAGNKS
TQSKDIKKAQEMIKLLEQGDSK
Download Length: 309 bp
>T166633 NZ_CP074363:3562080-3562337 [Xanthomonas translucens pv. secalis]
GTGACGCTTCAGTTCTCGGACAATGCCTGGGAGGACTACCTCTACTGGCAGCAGACCGACAAGAAGATGCTCAAGCGCAT
CAACGACCTGATCAAAGCCATTCAACGCGATCCCTTCCAGGGCGTCGGCAAGCCAGAACCGCTACGCCATGCCTTGGCCG
GCTATTGGTCGCGGCGCATCAACGACGAACATCGCATCGTGTACAAGGTCGAGGCGGGCGTCCTGCTGATCGCGCAGGTG
CGCTACCACTACGTGTAG
GTGACGCTTCAGTTCTCGGACAATGCCTGGGAGGACTACCTCTACTGGCAGCAGACCGACAAGAAGATGCTCAAGCGCAT
CAACGACCTGATCAAAGCCATTCAACGCGATCCCTTCCAGGGCGTCGGCAAGCCAGAACCGCTACGCCATGCCTTGGCCG
GCTATTGGTCGCGGCGCATCAACGACGAACATCGCATCGTGTACAAGGTCGAGGCGGGCGTCCTGCTGATCGCGCAGGTG
CGCTACCACTACGTGTAG
Antitoxin
Download Length: 106 a.a. Molecular weight: 11848.62 Da Isoelectric Point: 5.7250
>AT166633 WP_253703253.1 NZ_CP058347:835018-835335 [Treponema denticola]
MKITDFDPADYLTTKEAMIEYLNEALKTSIEDNTPEHFMEALGDVTRAQGITKAAKATDLNREHLYRSLSKKGNPTFTTI
IKLINFLGLEINISSQQKMKIALEV
MKITDFDPADYLTTKEAMIEYLNEALKTSIEDNTPEHFMEALGDVTRAQGITKAAKATDLNREHLYRSLSKKGNPTFTTI
IKLINFLGLEINISSQQKMKIALEV
Download Length: 318 bp
>AT166633 NZ_CP074363:3561832-3562083 [Xanthomonas translucens pv. secalis]
ATGGACACCATCACCTATAGCGCTGCACGCGCCGCCCTTGCGGACACCATGGAGCGCGTCGTCAACAACCACGAGCCGGT
GATCATCACCCGCAGCCGCGAGCAATCCGTGGTCATGCTGTCGCTTGAAGACTACAAGGCGATGGAGGAAACCGCCTACC
TGCTCCGCAGTCCGAAGAGCGCGCAGCGCCTGCTGGAATCCATCGCCCAGCTCGAGGCCGGTCGCGGCAAGGCACGGGAC
CTGGCCGAGTGA
ATGGACACCATCACCTATAGCGCTGCACGCGCCGCCCTTGCGGACACCATGGAGCGCGTCGTCAACAACCACGAGCCGGT
GATCATCACCCGCAGCCGCGAGCAATCCGTGGTCATGCTGTCGCTTGAAGACTACAAGGCGATGGAGGAAACCGCCTACC
TGCTCCGCAGTCCGAAGAGCGCGCAGCGCCTGCTGGAATCCATCGCCCAGCTCGAGGCCGGTCGCGGCAAGGCACGGGAC
CTGGCCGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|