Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4203702..4204297 Replicon chromosome
Accession NZ_CP058342
Organism Escherichia coli strain W60

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag HXP40_RS19980 Protein ID WP_000239579.1
Coordinates 4203702..4204052 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag HXP40_RS19985 Protein ID WP_001223208.1
Coordinates 4204046..4204297 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXP40_RS19960 4199148..4200170 - 1023 WP_001295197.1 ABC transporter permease -
HXP40_RS19965 4200184..4201686 - 1503 WP_000205784.1 sugar ABC transporter ATP-binding protein -
HXP40_RS19970 4201826..4202782 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
HXP40_RS19975 4203092..4203622 + 531 WP_000055072.1 inorganic diphosphatase -
HXP40_RS19980 4203702..4204052 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
HXP40_RS19985 4204046..4204297 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
HXP40_RS19990 4204509..4204850 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
HXP40_RS19995 4204853..4208632 - 3780 WP_000060978.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T166617 WP_000239579.1 NZ_CP058342:c4204052-4203702 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T166617 NZ_CP074359:2613417-2613524 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT166617 WP_001223208.1 NZ_CP058342:c4204297-4204046 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT166617 NZ_CP074359:c2613370-2613304 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References