Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 5504839..5505344 Replicon chromosome
Accession NZ_CP058333
Organism Pseudomonas aeruginosa strain ACR20

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HWQ57_RS25720 Protein ID WP_003083773.1
Coordinates 5505063..5505344 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag HWQ57_RS25715 Protein ID WP_003083775.1
Coordinates 5504839..5505066 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ57_RS25690 5499857..5501350 + 1494 WP_023109527.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
HWQ57_RS25695 5501519..5502946 + 1428 WP_003083784.1 GABA permease -
HWQ57_RS25700 5503028..5503369 - 342 WP_003101229.1 alkylphosphonate utilization protein -
HWQ57_RS25705 5503442..5503942 - 501 WP_003101228.1 LEA type 2 family protein -
HWQ57_RS25710 5504043..5504663 + 621 WP_003101226.1 hypothetical protein -
HWQ57_RS25715 5504839..5505066 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
HWQ57_RS25720 5505063..5505344 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HWQ57_RS25725 5505644..5506552 + 909 WP_003083769.1 LysR family transcriptional regulator -
HWQ57_RS25730 5506584..5506970 - 387 WP_014602345.1 aegerolysin family protein -
HWQ57_RS25735 5507174..5507908 - 735 WP_003117208.1 GntR family transcriptional regulator -
HWQ57_RS25740 5508009..5508695 - 687 WP_003083762.1 FadR family transcriptional regulator -
HWQ57_RS25745 5508744..5510093 - 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T166593 WP_003083773.1 NZ_CP058333:5505063-5505344 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T166593 NZ_CP074356:2877101-2877595 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT166593 WP_003083775.1 NZ_CP058333:5504839-5505066 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT166593 NZ_CP074356:2876811-2877104 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAACCAGGCGCGAATCTTTAAATTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGAGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References