Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 3792811..3794319 Replicon chromosome
Accession NZ_CP058333
Organism Pseudomonas aeruginosa strain ACR20

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag HWQ57_RS17805 Protein ID WP_003119682.1
Coordinates 3793732..3794319 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag HWQ57_RS17800 Protein ID WP_023109799.1
Coordinates 3792811..3793665 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ57_RS17785 3788230..3788439 + 210 WP_003091604.1 cold-shock protein -
HWQ57_RS17790 3788500..3790374 - 1875 WP_003091605.1 MFS transporter -
HWQ57_RS17795 3790549..3792714 - 2166 WP_003115567.1 TonB-dependent receptor family protein -
HWQ57_RS17800 3792811..3793665 - 855 WP_023109799.1 AraC family transcriptional regulator Antitoxin
HWQ57_RS17805 3793732..3794319 - 588 WP_003119682.1 GNAT family N-acetyltransferase Toxin
HWQ57_RS17810 3794585..3798064 + 3480 WP_003117605.1 hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T166592 WP_003119682.1 NZ_CP058333:c3794319-3793732 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T166592 NZ_CP074356:2751446-2751553 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31907.25 Da        Isoelectric Point: 7.5295

>AT166592 WP_023109799.1 NZ_CP058333:c3793665-3792811 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp

>AT166592 NZ_CP074356:c2751397-2751334 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References