Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2031209..2032429 Replicon chromosome
Accession NZ_CP058333
Organism Pseudomonas aeruginosa strain ACR20

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HWQ57_RS09635 Protein ID WP_023110128.1
Coordinates 2031209..2031787 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HWQ57_RS09640 Protein ID WP_003088112.1
Coordinates 2031875..2032429 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ57_RS09620 2026486..2027763 + 1278 WP_003102743.1 TolC family protein -
HWQ57_RS09625 2027753..2029924 + 2172 WP_023110129.1 type I secretion system permease/ATPase -
HWQ57_RS09630 2029914..2031101 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
HWQ57_RS09635 2031209..2031787 - 579 WP_023110128.1 HD domain-containing protein Toxin
HWQ57_RS09640 2031875..2032429 - 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
HWQ57_RS09645 2032587..2034782 - 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
HWQ57_RS09650 2034787..2035248 - 462 WP_023110127.1 (2Fe-2S)-binding protein -
HWQ57_RS09655 2035579..2035902 + 324 WP_003102734.1 multidrug efflux SMR transporter -
HWQ57_RS09660 2035915..2036313 + 399 WP_023082958.1 NADH-quinone oxidoreductase subunit A -
HWQ57_RS09665 2036310..2036861 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21841.69 Da        Isoelectric Point: 5.6184

>T166591 WP_023110128.1 NZ_CP058333:c2031787-2031209 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRGA

Download         Length: 579 bp

>T166591 NZ_CP074356:2750912-2751019 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT166591 WP_003088112.1 NZ_CP058333:c2032429-2031875 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT166591 NZ_CP074356:c2750859-2750798 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References