Detailed information of TA system TA166591

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 2031209..2032429
• Replicon: chromosome
• Accession: NZ_CP058333
• Organism: Pseudomonas aeruginosa strain ACR20

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HWQ57_RS09635
• Protein ID: WP_023110128.1
• Coordinates: 2031209..2031787 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HWQ57_RS09640
• Protein ID: WP_003088112.1
• Coordinates: 2031875..2032429 (-)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HWQ57_RS09620	2026486..2027763	+	1278	WP_003102743.1	TolC family protein	-
HWQ57_RS09625	2027753..2029924	+	2172	WP_023110129.1	type I secretion system permease/ATPase	-
HWQ57_RS09630	2029914..2031101	+	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
HWQ57_RS09635	2031209..2031787	-	579	WP_023110128.1	HD domain-containing protein	Toxin
HWQ57_RS09640	2031875..2032429	-	555	WP_003088112.1	helix-turn-helix domain-containing protein	Antitoxin
HWQ57_RS09645	2032587..2034782	-	2196	WP_003122807.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
HWQ57_RS09650	2034787..2035248	-	462	WP_023110127.1	(2Fe-2S)-binding protein	-
HWQ57_RS09655	2035579..2035902	+	324	WP_003102734.1	multidrug efflux SMR transporter	-
HWQ57_RS09660	2035915..2036313	+	399	WP_023082958.1	NADH-quinone oxidoreductase subunit A	-
HWQ57_RS09665	2036310..2036861	-	552	WP_003102727.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-188)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21841.69 Da
• Isoelectric Point: 5.6184

>T166591 WP_023110128.1 NZ_CP058333:c2031787-2031209 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRGA

Nucleotide

• Length: 579 bp

>T166591 NZ_CP074356:2750912-2751019 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT166591 WP_003088112.1 NZ_CP058333:c2032429-2031875 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT166591 NZ_CP074356:c2750859-2750798 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT