166585

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4585893..4587113 Replicon chromosome
Accession NZ_CP058332
Organism Pseudomonas aeruginosa strain B18

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag B18_RS21325 Protein ID WP_023110128.1
Coordinates 4585893..4586471 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag B18_RS21330 Protein ID WP_003088112.1
Coordinates 4586559..4587113 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B18_RS21310 4581170..4582447 + 1278 WP_003102743.1 TolC family protein -
B18_RS21315 4582437..4584608 + 2172 WP_023110129.1 type I secretion system permease/ATPase -
B18_RS21320 4584598..4585785 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
B18_RS21325 4585893..4586471 - 579 WP_023110128.1 HD domain-containing protein Toxin
B18_RS21330 4586559..4587113 - 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
B18_RS21335 4587271..4589466 - 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
B18_RS21340 4589471..4589932 - 462 WP_023110127.1 (2Fe-2S)-binding protein -
B18_RS21345 4590263..4590586 + 324 WP_003102734.1 multidrug efflux SMR transporter -
B18_RS21350 4590599..4590997 + 399 WP_023082958.1 NADH-quinone oxidoreductase subunit A -
B18_RS21355 4590994..4591545 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21841.69 Da        Isoelectric Point: 5.6184

>T166585 WP_023110128.1 NZ_CP058332:c4586471-4585893 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRGA

Download         Length: 579 bp

>T166585 NZ_CP074356:1832565-1832816 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT166585 WP_003088112.1 NZ_CP058332:c4587113-4586559 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT166585 NZ_CP074356:1832813-1833067 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CATTGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References