166580

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1569505..1570010 Replicon chromosome
Accession NZ_CP058332
Organism Pseudomonas aeruginosa strain B18

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag B18_RS07265 Protein ID WP_003083773.1
Coordinates 1569729..1570010 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag B18_RS07260 Protein ID WP_003083775.1
Coordinates 1569505..1569732 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B18_RS07235 1564523..1566016 + 1494 WP_023109527.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
B18_RS07240 1566185..1567612 + 1428 WP_003083784.1 GABA permease -
B18_RS07245 1567694..1568035 - 342 WP_003101229.1 alkylphosphonate utilization protein -
B18_RS07250 1568108..1568608 - 501 WP_003101228.1 LEA type 2 family protein -
B18_RS07255 1568709..1569329 + 621 WP_003101226.1 hypothetical protein -
B18_RS07260 1569505..1569732 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
B18_RS07265 1569729..1570010 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
B18_RS07270 1570310..1571218 + 909 WP_003083769.1 LysR family transcriptional regulator -
B18_RS07275 1571250..1571636 - 387 WP_014602345.1 aegerolysin family protein -
B18_RS07280 1571840..1572574 - 735 WP_003117208.1 GntR family transcriptional regulator -
B18_RS07285 1572675..1573361 - 687 WP_003083762.1 FadR family transcriptional regulator -
B18_RS07290 1573410..1574759 - 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T166580 WP_003083773.1 NZ_CP058332:1569729-1570010 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T166580 NZ_CP058332:1569729-1570010 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT166580 WP_003083775.1 NZ_CP058332:1569505-1569732 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT166580 NZ_CP058332:1569505-1569732 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References