166578

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5749152..5749766 Replicon chromosome
Accession NZ_CP058331
Organism Pseudomonas aeruginosa strain ACR22

Toxin (Protein)


Gene name hicA Uniprot ID A6VBH9
Locus tag HWQ50_RS26815 Protein ID WP_071534354.1
Coordinates 5749584..5749766 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A140SDX7
Locus tag HWQ50_RS26810 Protein ID WP_012077229.1
Coordinates 5749152..5749556 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ50_RS26785 5745292..5746002 + 711 WP_012074129.1 hypothetical protein -
HWQ50_RS26790 5745999..5746919 + 921 WP_012074128.1 hypothetical protein -
HWQ50_RS26795 5746916..5747455 + 540 WP_012074127.1 hypothetical protein -
HWQ50_RS26800 5747455..5748153 + 699 WP_033896049.1 hypothetical protein -
HWQ50_RS26805 5748138..5749109 + 972 WP_012077228.1 hypothetical protein -
HWQ50_RS26810 5749152..5749556 - 405 WP_012077229.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HWQ50_RS26815 5749584..5749766 - 183 WP_071534354.1 type II toxin-antitoxin system HicA family toxin Toxin
HWQ50_RS26820 5750309..5751241 - 933 WP_003120918.1 ZIP family metal transporter -
HWQ50_RS26825 5751260..5751871 - 612 WP_003098862.1 superoxide dismutase -
HWQ50_RS26830 5751884..5752333 - 450 WP_003094369.1 hypothetical protein -
HWQ50_RS26835 5752361..5753737 - 1377 WP_003098863.1 class II fumarate hydratase -
HWQ50_RS26840 5753730..5754125 - 396 WP_003094374.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5716109..5749766 33657


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6702.74 Da        Isoelectric Point: 10.4826

>T166578 WP_071534354.1 NZ_CP058331:c5749766-5749584 [Pseudomonas aeruginosa]
MRSREVIDLLLEDGWYEVAVKGSHHQFKHPSKPGKVTVQHPSSTIPKGTLNNILKQAGLK

Download         Length: 183 bp

>T166578 NZ_CP074354:c4070436-4070086 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATAACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14670.54 Da        Isoelectric Point: 4.4315

>AT166578 WP_012077229.1 NZ_CP058331:c5749556-5749152 [Pseudomonas aeruginosa]
MKFPVVLHKDPDSDYGVTVPDVPGCFSAGATVSEALANVEEALALHFEGLVTDGEELPQPQDVDAHMKNPDFEGGVWAVV
DFDVTPYLGKAVRFNATLPEHLLQRIDERVKVDKRYQSRSGFLATAAMRELSVA

Download         Length: 405 bp

>AT166578 NZ_CP074354:c4070681-4070430 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6VBH9

Antitoxin

Source ID Structure
AlphaFold DB A0A140SDX7

References