Detailed information of TA system TA166575

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 4176976..4178196
• Replicon: chromosome
• Accession: NZ_CP058331
• Organism: Pseudomonas aeruginosa strain ACR22

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HWQ50_RS19340
• Protein ID: WP_023110128.1
• Coordinates: 4177618..4178196 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HWQ50_RS19335
• Protein ID: WP_003088112.1
• Coordinates: 4176976..4177530 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HWQ50_RS19310	4172544..4173095	+	552	WP_003102727.1	XRE family transcriptional regulator	-
HWQ50_RS19315	4173092..4173490	-	399	WP_023082958.1	NADH-quinone oxidoreductase subunit A	-
HWQ50_RS19320	4173503..4173826	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
HWQ50_RS19325	4174157..4174618	+	462	WP_023110127.1	(2Fe-2S)-binding protein	-
HWQ50_RS19330	4174623..4176818	+	2196	WP_003122807.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
HWQ50_RS19335	4176976..4177530	+	555	WP_003088112.1	helix-turn-helix domain-containing protein	Antitoxin
HWQ50_RS19340	4177618..4178196	+	579	WP_023110128.1	HD domain-containing protein	Toxin
HWQ50_RS19345	4178304..4179491	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
HWQ50_RS19350	4179481..4181652	-	2172	WP_023110129.1	type I secretion system permease/ATPase	-
HWQ50_RS19355	4181642..4182919	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-188)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21841.69 Da
• Isoelectric Point: 5.6184

>T166575 WP_023110128.1 NZ_CP058331:4177618-4178196 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRGA

Nucleotide

• Length: 579 bp

>T166575 NZ_CP074354:3443067-3443609 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT166575 WP_003088112.1 NZ_CP058331:4176976-4177530 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT166575 NZ_CP074354:3442772-3443083 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA