Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4417382..4418039 Replicon chromosome
Accession NZ_CP058325
Organism Klebsiella pneumoniae subsp. pneumoniae strain LC-1825/18

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GLO21_RS21720 Protein ID WP_002916310.1
Coordinates 4417382..4417792 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GLO21_RS21725 Protein ID WP_002916312.1
Coordinates 4417773..4418039 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GLO21_RS21700 (GLO21_021695) 4413382..4415115 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
GLO21_RS21705 (GLO21_021700) 4415121..4415834 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GLO21_RS21710 (GLO21_021705) 4415857..4416753 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GLO21_RS21715 (GLO21_021710) 4416854..4417375 + 522 WP_002916308.1 flavodoxin FldB -
GLO21_RS21720 (GLO21_021715) 4417382..4417792 - 411 WP_002916310.1 protein YgfX Toxin
GLO21_RS21725 (GLO21_021720) 4417773..4418039 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GLO21_RS21730 (GLO21_021725) 4418285..4419268 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
GLO21_RS21735 (GLO21_021730) 4419419..4420078 - 660 WP_002916317.1 hemolysin III family protein -
GLO21_RS21740 (GLO21_021735) 4420242..4420553 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
GLO21_RS21745 (GLO21_021740) 4420603..4421331 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
GLO21_RS21750 (GLO21_021745) 4421450..4422883 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T166566 WP_002916310.1 NZ_CP058325:c4417792-4417382 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T166566 NZ_CP074354:866367-866774 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTCGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT166566 WP_002916312.1 NZ_CP058325:c4418039-4417773 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT166566 NZ_CP074354:866120-866386 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References