Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2606235..2607823 | Replicon | chromosome |
| Accession | NZ_CP058325 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain LC-1825/18 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | W8UI36 |
| Locus tag | GLO21_RS12790 | Protein ID | WP_002904792.1 |
| Coordinates | 2606501..2607823 (+) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A0H3GXD8 |
| Locus tag | GLO21_RS12785 | Protein ID | WP_002904790.1 |
| Coordinates | 2606235..2606501 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GLO21_RS12760 (GLO21_012765) | 2601385..2602308 | + | 924 | WP_002904781.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
| GLO21_RS12765 (GLO21_012770) | 2602289..2603443 | - | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
| GLO21_RS12770 (GLO21_012775) | 2603789..2605168 | + | 1380 | WP_002904785.1 | nucleobase:cation symporter-2 family protein | - |
| GLO21_RS12775 (GLO21_012780) | 2605146..2605646 | + | 501 | WP_002904787.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| GLO21_RS12780 (GLO21_012785) | 2605643..2605969 | + | 327 | WP_002904788.1 | hydroxyisourate hydrolase | - |
| GLO21_RS12785 (GLO21_012790) | 2606235..2606501 | + | 267 | WP_002904790.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| GLO21_RS12790 (GLO21_012795) | 2606501..2607823 | + | 1323 | WP_002904792.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| GLO21_RS12795 (GLO21_012800) | 2607840..2609132 | - | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
| GLO21_RS12800 (GLO21_012805) | 2609274..2610278 | - | 1005 | WP_002904798.1 | fimbrial protein | - |
| GLO21_RS12805 (GLO21_012810) | 2610266..2612767 | - | 2502 | WP_004151634.1 | fimbria/pilus outer membrane usher protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49171.46 Da Isoelectric Point: 7.5357
>T166557 WP_002904792.1 NZ_CP058325:2606501-2607823 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
>T166557 NZ_CP074352:c166636-166232 [Siccibacter colletis]
ATGCTCAAGTTTATGCTGGACACGAATATCTGCATTTTCACTATCAAAAATAAACCGCAGATCGTGCGTGACGCTTTCAA
TAAATATTACGGACAAATGTGCATCAGCACCGTCACGCTAATGGAATTGATATACGGCGCAGAAAAATCACAAAACCCGG
AAAGAAACCTGGCCGTCGTCGAAGGGTTTGCTGCCCGTCTGGATGTGCTTACGTTTGATAACGATGCCGCTACGCATACG
GGTCAGATCCGGGCTGACCTCGCTAAAAAAGGAACCCCTATTGGAGCCTGGGACAACATGATCGCCGGTCATGCGCGTTC
CCGGGGCTTGATCGTGGTAACGAACAACACGCGGGAGTTTGAGCGCGTGTCAGGGTTGCGCACCGAAGACTGGATTGCCG
GATAA
ATGCTCAAGTTTATGCTGGACACGAATATCTGCATTTTCACTATCAAAAATAAACCGCAGATCGTGCGTGACGCTTTCAA
TAAATATTACGGACAAATGTGCATCAGCACCGTCACGCTAATGGAATTGATATACGGCGCAGAAAAATCACAAAACCCGG
AAAGAAACCTGGCCGTCGTCGAAGGGTTTGCTGCCCGTCTGGATGTGCTTACGTTTGATAACGATGCCGCTACGCATACG
GGTCAGATCCGGGCTGACCTCGCTAAAAAAGGAACCCCTATTGGAGCCTGGGACAACATGATCGCCGGTCATGCGCGTTC
CCGGGGCTTGATCGTGGTAACGAACAACACGCGGGAGTTTGAGCGCGTGTCAGGGTTGCGCACCGAAGACTGGATTGCCG
GATAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9906.27 Da Isoelectric Point: 8.5912
>AT166557 WP_002904790.1 NZ_CP058325:2606235-2606501 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
Download Length: 267 bp
>AT166557 NZ_CP074352:c166866-166636 [Siccibacter colletis]
ATGGAAAAAACCACCGTGTTTCGTAGTAATCGCAGCCAGGCCGTGCGCTTACCTAAAGCGGTAGCGCTACCGGAAGATGT
CAAAAATGTAGAAATCGTTGCCATCGGCAGAACCCGGATCATCACACCGGCTGGCGAAGGCTGGGACACCTGGTTCAACG
GCGATAGCGTGACGTCGGACTATATGTCTGACAGGGATCAACCAGACGATCAGACCAGGGAAGAATTTTGA
ATGGAAAAAACCACCGTGTTTCGTAGTAATCGCAGCCAGGCCGTGCGCTTACCTAAAGCGGTAGCGCTACCGGAAGATGT
CAAAAATGTAGAAATCGTTGCCATCGGCAGAACCCGGATCATCACACCGGCTGGCGAAGGCTGGGACACCTGGTTCAACG
GCGATAGCGTGACGTCGGACTATATGTCTGACAGGGATCAACCAGACGATCAGACCAGGGAAGAATTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E1CEC8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GXD8 |