Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 510362..510878 Replicon chromosome
Accession NZ_CP058325
Organism Klebsiella pneumoniae subsp. pneumoniae strain LC-1825/18

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag GLO21_RS02465 Protein ID WP_002886902.1
Coordinates 510594..510878 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag GLO21_RS02460 Protein ID WP_002886901.1
Coordinates 510362..510604 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GLO21_RS02445 (GLO21_002445) 506391..507131 + 741 WP_002886899.1 KDGP aldolase family protein -
GLO21_RS02450 (GLO21_002450) 507197..508351 + 1155 WP_002886900.1 lactonase family protein -
GLO21_RS02455 (GLO21_002455) 508374..510284 + 1911 WP_004152270.1 PRD domain-containing protein -
GLO21_RS02460 (GLO21_002460) 510362..510604 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GLO21_RS02465 (GLO21_002465) 510594..510878 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GLO21_RS02470 (GLO21_002470) 510882..511346 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GLO21_RS02475 (GLO21_002475) 511587..513725 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
GLO21_RS02480 (GLO21_002480) 514082..514825 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
GLO21_RS02485 (GLO21_002485) 514828..515001 - 174 WP_002886906.1 hypothetical protein -
GLO21_RS02490 (GLO21_002490) 515131..515394 + 264 WP_004152271.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T166554 WP_002886902.1 NZ_CP058325:510594-510878 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T166554 NZ_CP074352:64910-65284 [Siccibacter colletis]
ATGGAGGGCGTGGCGGTATTCGATACCAACATCCTTATCGATCTATTTAGTGGGCATCAGCAGGCGGCAGAGGTGATGGA
ACAGTATCCCATTAATCGCGGCATCAGCCTGATGACATGGATTGAAGTAATGGTAGGGGCAAAAAAACACGGTCAGGAAA
TACGTACGCGTGAGGTACTGGAGGCGTTTGATGTGTTGCCGATTTCAGCCGCAGTGGCTGAACGCAGCGTAATGATTCGT
CAACAGCACGGCATGAAACTGCCTGATGCCATCATTCTGGCAACGGCGCAGGTTAATTCTCGTTTGCTGGTAACGCGCAA
CTCGAAGGATTTCGCCGGCATAAGCGGCGTAACGATTCCCTACAATTTAAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT166554 WP_002886901.1 NZ_CP058325:510362-510604 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT166554 NZ_CP074352:64665-64907 [Siccibacter colletis]
ATGGTCATGACAGCAGAGAACATTATGGGACGAATTCTTCTCGACTTACCTGACGAGGCGATTCGCCGCCTCGATCACCT
TAAACAGCGCCGCAACACCGCCAGAGCGGAGCTACTGCGCGAAGCGATTGAGCAGTATCTGGAAAGGCAGACACAAAATG
TTCTTCACGAGGCGTTAGGCCTGTGGGGGGAGGCGGCTGAAGATGGGCTGGAGTATGAGCGAAAACTACGTGAGGAGTGG
TAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References