Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 350365..352046 Replicon chromosome
Accession NZ_CP058325
Organism Klebsiella pneumoniae subsp. pneumoniae strain LC-1825/18

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag GLO21_RS01650 Protein ID WP_002885155.1
Coordinates 351129..352046 (+) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag GLO21_RS01645 Protein ID WP_004151732.1
Coordinates 350365..351123 (+) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GLO21_RS01630 (GLO21_001630) 346215..346901 - 687 WP_004151733.1 tetratricopeptide repeat protein -
GLO21_RS01635 (GLO21_001635) 347131..349278 - 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
GLO21_RS01640 (GLO21_001640) 349551..350279 + 729 WP_002885152.1 response regulator transcription factor -
GLO21_RS01645 (GLO21_001645) 350365..351123 + 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
GLO21_RS01650 (GLO21_001650) 351129..352046 + 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
GLO21_RS01655 (GLO21_001655) 352171..353178 - 1008 WP_004151731.1 carbohydrate kinase family protein -
GLO21_RS01660 (GLO21_001660) 353253..354194 - 942 WP_002885156.1 ABC transporter substrate-binding protein -
GLO21_RS01665 (GLO21_001665) 354225..355223 - 999 WP_002885172.1 ribose ABC transporter permease -
GLO21_RS01670 (GLO21_001670) 355220..356740 - 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T166553 WP_002885155.1 NZ_CP058325:351129-352046 [Klebsiella pneumoniae subsp. pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T166553 NZ_CP074352:40212-40787 [Siccibacter colletis]
ATGGAACACTCACCTTATCCCGTTGTGCTGGATGCATGCGTGCTTTATCCAGCACGATTAAGGGATTTGCTGATGCATCT
GGGGATAGCGGGATTATATCAGCCGAAATGGAGTGCTGAGATCCATCGCGAATGGTGCCGAAATCTGTTGATGAACCGAC
CGGATATTACCCAGGCAGCATTAACGCGCACCGTTGAGTTGATGGAGAAGGCGCTTCCTGACGCTCGCGTGGTGGGCTTC
GAAACCCTCATTGAGGGGCTTACGCTTCCTGATGAAAATGACCGCCATGTGTTGGCCGTGGCGTTACGCGCAAAAGCCGA
AGTCATCGTGACGCTAAATCAAAAAGATTTTCCTGCCTCCGCCCTGCAAAAATTTAATATCGAAGCGTTGCATCCGGACG
ATTTTATCACTGACCTGCTTGATCTCAGTCCGGGCATCGCACTCGAAGCCGTCAGGCGTCAACGGCAGTCGCTCCGACAC
CCTCCTCTCTCAATAGATGATTTTCTGGATATGCTGCTGAAGCAGGGTCTTAATGGCACTGTCAGCGTTCTCAAAGGATA
TCGTCAGGCCATCTGA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT166553 WP_004151732.1 NZ_CP058325:350365-351123 [Klebsiella pneumoniae subsp. pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT166553 NZ_CP074352:39754-40212 [Siccibacter colletis]
ATGACCACCTCATTAACCGCACTCGAGCTCCCGGACGCACGCGAAAGCGAGCTGGCGCAGCGAGGCCAGCAGGAACTGGC
GGCATTCCTCTCAACAAAATTTGAAACGCAGCGTATCGCAATCGTTGGGGACGATAACCAAACCCATACTATTGAGCTGC
CTGCCAGAGCGCTGAGCATGTTGAGGGATATCCTCGGCGAGCTGGCCGCGGGCAACGCTGTGCAAGTTGTGCCGATTCAT
GCGGAACTCACTACGCAAGAAGCAGCTAACATGCTTAACGTTTCACGTCCTCATATGGTGAAATTGCTTGAGGACGGGAA
ATTGCCGTTCCACAAAACCGGGCGGCATCGTCGCGTGTTGTTTGCCGATCTGATGGAATATAAACAGAAACGGGAACACG
AAAGCCTCGAGGCCATGCAGGCGCTTGCGGACCAGGCGCAGGACACAGGGATGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References