Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 5838833..5839576 Replicon chromosome
Accession NZ_CP058322
Organism Micromonospora carbonacea strain aurantiaca

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HXZ27_RS24185 Protein ID WP_178066047.1
Coordinates 5838833..5839207 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HXZ27_RS24190 Protein ID WP_181019396.1
Coordinates 5839298..5839576 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXZ27_RS24160 5834413..5835462 + 1050 WP_083302629.1 iron chelate uptake ABC transporter family permease subunit -
HXZ27_RS24165 5835510..5836535 + 1026 WP_178067725.1 iron chelate uptake ABC transporter family permease subunit -
HXZ27_RS24170 5836520..5837410 + 891 WP_178066045.1 ABC transporter ATP-binding protein -
HXZ27_RS24175 5837340..5838431 - 1092 WP_178066046.1 hypothetical protein -
HXZ27_RS24180 5838582..5838836 + 255 WP_178067727.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
HXZ27_RS24185 5838833..5839207 + 375 WP_178066047.1 type II toxin-antitoxin system VapC family toxin Toxin
HXZ27_RS24190 5839298..5839576 + 279 WP_181019396.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HXZ27_RS24195 5839573..5839983 + 411 WP_178066049.1 type II toxin-antitoxin system VapC family toxin -
HXZ27_RS24200 5840090..5841145 - 1056 WP_178066050.1 NADP-dependent oxidoreductase -
HXZ27_RS24205 5841147..5842847 - 1701 WP_178067729.1 NAD(P)/FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(4-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13633.78 Da        Isoelectric Point: 5.4747

>T166551 WP_178066047.1 NZ_CP058322:5838833-5839207 [Micromonospora carbonacea]
MTLLLDTHVALWAITGDATLGVDFLDQLRHDPDILLSPVTLWEITIKQGAGKLVGPPDLAERVREMGFRELPVTHAHAIA
ASRLPPHHRDPFDRMLVAQAITEGLTLATRDASIALYDVDVLKV

Download         Length: 375 bp

>T166551 NZ_CP074351:579056-579427 [Pantoea dispersa]
GTGTGGCAGGTTGAAGCAACAGATCGGTTTTGTAAATGGTTGCAGGCTCAGGATGAAGCGTTGCGTCTCGACGTGCTTGC
CGCCCTGAAGCTTCTGGCGCAGGACGGTCCGCATCTTGGCCGCCCTTTCGTTGATACCCTGATGTTATCGCGGGTGCCCA
ATATGAAAGAGCTTCGCGTGCAAAGTAAAGGTCGTCCCATCCGCAGCTTTTTTGTTTTCGATCCGCGCCGCCATGCGATT
GTGCTGTGTGCCGGCAACAAACAGGGTAAAAATCAGAAGCGTTTCTATCAGCAGATGCTTCGCATTGCCGAAACCGAATA
CCATCATCATCTGAACGCAATCGGGGAAACTCATAATGAAAACCTTGGATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9753.03 Da        Isoelectric Point: 4.5859

>AT166551 WP_181019396.1 NZ_CP058322:5839298-5839576 [Micromonospora carbonacea]
MERIGVRELNQNTSQVLARVSGGETVEITDRGHPIARLVPVGDDRSMLARLVAAGRAVAPTGGGPVPLPPQLGDEDVDVA
ATLAAMRDEERW

Download         Length: 279 bp

>AT166551 NZ_CP074351:579411-579710 [Pantoea dispersa]
ATGAAAACCTTGGATGAGATGCTGGCGGCGCTGACGCCCGAACAGCAACATCAGGTCGATGAACGCGTCAGCCAGATGCG
TCTTGAATACCAGCTTTACCAATTACGTGAGCAGATGCAGCGGACTCAGCGTCAGCAAGCGCAGGCCATGCACATTGCCC
AGTCATCTGTGGCGGCGATGGAAGCGCGTGGCGCAGAGTTAAAAATTTCCACGCTGAAGCGCTACATTGAGGCGCTGGGT
GGAGAGCTGACGCTGGGTGTAAAGATGCCGGGTGGCCAGCATGTCGACTTAATTATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References