Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 2323396..2323931 Replicon chromosome
Accession NZ_CP058322
Organism Micromonospora carbonacea strain aurantiaca

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HXZ27_RS10115 Protein ID WP_178064041.1
Coordinates 2323677..2323931 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag HXZ27_RS10110 Protein ID WP_178064040.1
Coordinates 2323396..2323680 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXZ27_RS10095 2318578..2319027 + 450 WP_043962656.1 transcriptional repressor -
HXZ27_RS10100 2319051..2321327 + 2277 WP_178064038.1 catalase/peroxidase HPI -
HXZ27_RS10105 2321399..2322949 - 1551 WP_178064039.1 TROVE domain-containing protein -
HXZ27_RS10110 2323396..2323680 + 285 WP_178064040.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HXZ27_RS10115 2323677..2323931 + 255 WP_178064041.1 Txe/YoeB family addiction module toxin Toxin
HXZ27_RS10120 2323974..2324927 - 954 WP_178064042.1 class I mannose-6-phosphate isomerase -
HXZ27_RS10125 2324924..2326129 - 1206 WP_178064043.1 hypothetical protein -
HXZ27_RS10130 2326131..2326994 - 864 WP_178064044.1 ketose-bisphosphate aldolase -
HXZ27_RS10135 2327029..2327871 - 843 WP_178064045.1 carbohydrate ABC transporter permease -
HXZ27_RS10140 2327873..2328829 - 957 WP_178064046.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10271.56 Da        Isoelectric Point: 9.9423

>T166550 WP_178064041.1 NZ_CP058322:2323677-2323931 [Micromonospora carbonacea]
VKVQFASRGWEDYQAWQRDRPMLKRVNTLIEEIRRNGHQGIGKPEQLRGNWSGFWSRRIDQEHRLVYRIVDDTVQIAQCR
YHYE

Download         Length: 255 bp

>T166550 NZ_CP074350:c4059005-4058706 [Pantoea dispersa]
ATGCAAACGGAACCGGAGTTTGAGTGGGATACCACCAAGGCGGAAACAAATTTCCGCAAGCATGGTATCCGCTTTGAAGT
TGCAGCCCGCGTGTTTGAGGATCCTTTCCACCTGTCGATGCAGGATCGTTATGAAAATGGGGAATATCGCTGGCAAACCA
TTGGTAATGTTATGGGGCATGTGGTCATTCTGGTGGCCCATACGGTGCGCTTCGAAACAGATGTTGAGCGAATAAGGATT
ATCAGCGCACGCCATGCAACGCGTATTGAGAGGAGGCGCTATGAGCAAAGTCAGGTTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10270.48 Da        Isoelectric Point: 4.3529

>AT166550 WP_178064040.1 NZ_CP058322:2323396-2323680 [Micromonospora carbonacea]
MRMVPYSEVRQNLAKLLDHVVDDAEEVVVTRSGREAAVIISLREYESLKETAYLMASPANARRLNEAVEELRNGGGEMHD
LIDPDASAGEASAA

Download         Length: 285 bp

>AT166550 NZ_CP074350:c4058725-4058423 [Pantoea dispersa]
ATGAGCAAAGTCAGGTTTAAACGCAGTGAATTACCGCCGCTCACCGATAAGCAACAGGCGGAGCTGGATGCTTTGAGCCG
GAAACAGGACAGCGACATCCAGTTTGATGATATTGCGCCGTTAGACGACAGTTTCTGGCAGGCTGCCGAACGGGGGCGTT
TTTACCGCCCGGTAAAAACCCAGGCTTCGATCAGAATCGATGCGGATATTCTTGAGTGGTTAAAGGCGCCTGGCAAAGGT
TACCAGACGCGCCTCAACGCGATCCTGCGAGCCGCGATGCTAAGAGAACTGCAGGGTAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References