Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 813004..813551 Replicon chromosome
Accession NZ_CP058321
Organism Halomonas sp. SH5A2

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag HXW73_RS03870 Protein ID WP_186254985.1
Coordinates 813004..813303 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag HXW73_RS03875 Protein ID WP_186254986.1
Coordinates 813303..813551 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXW73_RS03845 808105..809031 + 927 WP_186254981.1 Rpn family recombination-promoting nuclease/putative transposase -
HXW73_RS03850 809575..810396 + 822 WP_186254982.1 type IV toxin-antitoxin system AbiEi family antitoxin -
HXW73_RS03855 810465..810608 + 144 Protein_741 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
HXW73_RS03860 810605..811474 - 870 WP_186254983.1 LysR family transcriptional regulator -
HXW73_RS03865 811663..812817 + 1155 WP_186254984.1 MFS transporter -
HXW73_RS03870 813004..813303 - 300 WP_186254985.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HXW73_RS03875 813303..813551 - 249 WP_186254986.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HXW73_RS03880 813736..813894 + 159 Protein_746 DeoR family transcriptional regulator -
HXW73_RS03885 813978..814940 - 963 WP_186254948.1 IS1595 family transposase -
HXW73_RS03890 815164..816162 + 999 WP_186254987.1 virulence protein RhuM/Fic/DOC family protein -
HXW73_RS03895 816174..816707 - 534 WP_186254988.1 hypothetical protein -
HXW73_RS03900 816744..816881 - 138 Protein_750 DUF1330 domain-containing protein -
HXW73_RS03905 816953..817471 - 519 WP_186254989.1 cupin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 802658..813551 10893
- flank IS/Tn - - 813978..814940 962


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-89)

Antitoxin

Antitoxin ParD

(3-81)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11719.31 Da        Isoelectric Point: 8.4234

>T166545 WP_186254985.1 NZ_CP058321:c813303-813004 [Halomonas sp. SH5A2]
MPTFHITPRARDDLKNIGRYTERQWGRSQRNIYLKDFEKRFHWLAENPLLGKHRADISEGYYSYPQGQHVIFYLIGQGGI
EIIGIPHKEVDIVSYFLPD

Download         Length: 300 bp

>T166545 NZ_CP074350:1960391-1960567 [Pantoea dispersa]
GTGAAGCAAAGCGAGTTCAGGCGGTGGCTTGAATCTCAGGGAGTCGAAGTTTCAAACGGTACTAACCACCTGAAACTGAG
ATATAACGGGAAGCGTAGCGTAATGCCCAGGCATCCCGGCTCTGAATTAAAAGAACCACTGCGAAAGGCCATAATTAAGC
AACTTGGCCTGAAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9157.09 Da        Isoelectric Point: 4.5201

>AT166545 WP_186254986.1 NZ_CP058321:c813551-813303 [Halomonas sp. SH5A2]
MATTSLSLGEHWEVFIRNEVSSGRYGSASEVVRDALRAMEERKSKIEALRTHLAQGAEQARAGEFVDDFSVDSLINDLDR
ET

Download         Length: 249 bp

>AT166545 NZ_CP074350:1960616-1961023 [Pantoea dispersa]
ATGCGATACCCGATAAATCTTGAGCCATGCGATGGCGGATATGTGGTTTCGTTCCCCGATATCCCGGAGGCTTTAACGCA
GGGTGATACCCTTGAAGAAGCCATGGCGATGGGGCTTGATGCGCTGGTGACGGCGTTTGAGTTCTACTTCGAAGACGGGA
ATAAGGTCCCTGAACCGTCAGAGGTGGCGGGGGATTATGTAGAAGTGCCAGCCAGCGTGGTGGCAAAAGTGCTTATGCTT
AGCGCCTTTATCGATTCCGGCTTAACTCAGGTTGAGCTGGCGTCGCGCATGGGGGTGAAAAAGCAGGAGGTTACGCGGCT
TTTCGACCTTCAGCACGCAACAAAAATCGACACCATCCAGAAAGCGCTATCAGCGCTGGGCCGGCGACTGGAAATGACCG
CCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References