Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 2264827..2265382 Replicon chromosome
Accession NZ_CP058315
Organism Treponema parvum strain OMZ 843

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HXT04_RS10225 Protein ID WP_210121355.1
Coordinates 2265107..2265382 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HXT04_RS10220 Protein ID WP_210121354.1
Coordinates 2264827..2265117 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXT04_RS10205 (HXT04_10215) 2260402..2261847 - 1446 WP_210117812.1 TrkH family potassium uptake protein -
HXT04_RS10210 (HXT04_10220) 2261850..2263295 - 1446 WP_210121352.1 NAD-binding protein -
HXT04_RS10215 (HXT04_10225) 2263488..2264528 - 1041 WP_210121353.1 C45 family peptidase -
HXT04_RS10220 (HXT04_10230) 2264827..2265117 + 291 WP_210121354.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HXT04_RS10225 (HXT04_10235) 2265107..2265382 + 276 WP_210121355.1 type II toxin-antitoxin system YafQ family toxin Toxin
HXT04_RS10230 (HXT04_10240) 2265570..2266514 + 945 WP_210122384.1 peptide-methionine (R)-S-oxide reductase MsrB -
HXT04_RS10235 (HXT04_10245) 2266674..2267138 + 465 WP_210121356.1 peroxiredoxin -
HXT04_RS10240 (HXT04_10250) 2267145..2267675 + 531 WP_210121357.1 GNAT family N-acetyltransferase -
HXT04_RS10245 (HXT04_10255) 2267672..2268451 + 780 WP_210121358.1 hypothetical protein -
HXT04_RS10250 (HXT04_10260) 2268564..2269523 + 960 WP_210121359.1 bile acid:sodium symporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-72)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10787.58 Da        Isoelectric Point: 9.5366

>T166543 WP_210121355.1 NZ_CP058315:2265107-2265382 [Treponema parvum]
MKYKFDYTTRFKKDYRKLIDQSVIDEVDTVIEKLLNGKLLEKKYKDHALSGSYKGCRDCHIRPDLVLIYKKNNEILVLTA
LRVGTHSELFY

Download         Length: 276 bp

>T166543 NZ_CP074350:177797-178096 [Pantoea dispersa]
ATGGGTTCAATCAGGGCGTTTCGTCAGGCCTGGCTGGCACAATTTTATACCCATGGGACACCGCATGCGCAGATTCCGCG
TGCGATTGAATCAGCGCTGGCGCGTAAGCTGGATATCATTCATGCCGCCACTTCGCATCAGGATTTGCGTTCGCCGCCGG
GTAACCGTTTTGAAGCGTTAAAGCCGCCGCTGCTGGGTTATTATTCGATTCGGGTTAACGCGCAGTATCGGCTAATTTTC
CAGTGGGCAAAAGGCGAAGCCTGGGATCTGTATCTGGATCCGCACCGCTACAAAAAATAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10814.38 Da        Isoelectric Point: 10.0511

>AT166543 WP_210121354.1 NZ_CP058315:2264827-2265117 [Treponema parvum]
MAKAASFSIRMDSDIKKQSESLYNALGLNLTTAINVFLRKSIQAGGFPFDVRLDNFNNETVQAIKEADFIAEEIKSGRRK
PFTSWEKAKKSLINEI

Download         Length: 291 bp

>AT166543 NZ_CP074350:178145-178477 [Pantoea dispersa]
ATGAAACAAGCAATGCGCAAACCCACCAGCGTGGGGGACGTCCTGCAGTATGAATTTCTCGAACCGCTCAACCTCAAAGT
GAATGATCTGGCGGAGATGCTGAATGTGCATCGCAACACCGTCAGCGCGCTGGTGAATAACAACCGTAAACTCAGCACTG
AGATGGCCTACCGGCTGGCACGGGTTTTCGCCACCTCGATTGAATTCTGGCTTAACCTGCAGCGTCATCTCGATCAGTGG
GAAGTGGAAAATGACGCCAGAACGCAGGAGGAGTTAAGCCGTGTCATGACGCTGAGTGCCTTTTTAGCCCAGCGCGGCAC
GCAGGTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References