Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1244483..1245074 Replicon chromosome
Accession NZ_CP058315
Organism Treponema parvum strain OMZ 843

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HXT04_RS05610 Protein ID WP_210122261.1
Coordinates 1244811..1245074 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HXT04_RS05605 Protein ID WP_210122260.1
Coordinates 1244483..1244824 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXT04_RS05585 (HXT04_05585) 1239819..1240886 + 1068 WP_210122256.1 ATP-binding cassette domain-containing protein -
HXT04_RS05590 (HXT04_05590) 1240903..1241583 + 681 WP_210122257.1 Crp/Fnr family transcriptional regulator -
HXT04_RS05595 (HXT04_05595) 1241712..1243346 + 1635 WP_210122258.1 hydroxylamine reductase -
HXT04_RS05600 (HXT04_05600) 1243606..1244253 - 648 WP_210122259.1 Vat family streptogramin A O-acetyltransferase -
HXT04_RS05605 (HXT04_05605) 1244483..1244824 - 342 WP_210122260.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HXT04_RS05610 (HXT04_05610) 1244811..1245074 - 264 WP_210122261.1 type II toxin-antitoxin system HicA family toxin Toxin
HXT04_RS05615 (HXT04_05615) 1245283..1246116 - 834 WP_210122262.1 carbohydrate ABC transporter permease -
HXT04_RS05620 (HXT04_05620) 1246117..1247016 - 900 WP_210122263.1 sugar ABC transporter permease -
HXT04_RS05625 (HXT04_05625) 1247072..1248337 - 1266 WP_210122264.1 sugar ABC transporter substrate-binding protein -
HXT04_RS05630 (HXT04_05630) 1248351..1249493 - 1143 WP_210122265.1 enolase C-terminal domain-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-82)

Antitoxin

Uncharacterised protein family HicB

(52-102)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9878.27 Da        Isoelectric Point: 10.3448

>T166542 WP_210122261.1 NZ_CP058315:c1245074-1244811 [Treponema parvum]
VNTKQQKIYCTIFKNPVQSNIKWQDIENLLKSLGASISEGNGSRVRIELNGERAVFHRPHPEKITDKGAVKSMRRFLENA
GVKNDDL

Download         Length: 264 bp

>T166542 NZ_CP074350:c6891-6538 [Pantoea dispersa]
ATGTGGGAAATCATTTTTACCGACACCTTCCGGGAATGGTTGCGGGCACAGGATAACAAACTGAAAAAACGCATCGCTGC
GGCCCTGTTAAACCTGCAGCATTATGGCCCGTTGTTGCCACGGCCCTATGCCGATACGGTTAACGGATCACGCTTCCACA
ACATGAAAGAACTGAGAATACAGTACGCTGGTCAGCCAATTCGGGCGCTATACGCATTCAACACGCAACGCAAAGCGGTC
ATTTTGTGTGCTGGCAATAAATCCGGAGACAAACAATTTTATGCGCGGATGATATGCCTTGCAGATCAATTGTTCACGGC
TTACCTCAATAACGCAGAGGAAAATCATTCATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12973.64 Da        Isoelectric Point: 4.3068

>AT166542 WP_210122260.1 NZ_CP058315:c1244824-1244483 [Treponema parvum]
MMTYKGFIATVEYDDEAHVFTGEVINTRTVITFQGTTVDEMENEFRASVDDYLEWCKEDGIEPEKPYSGKFNVRLSPLFH
SQVALAAKKLDMSLNSFVEKSLKDEISNMQLVY

Download         Length: 342 bp

>AT166542 NZ_CP074350:c6541-6236 [Pantoea dispersa]
ATGAACGACTTACAAAAATTTATCGAGAGTGAGTTTACTGAAGCTGAGCAAGCTGACATTCAGCTGATGGCAGATGAGCT
GATTCTCGAAACCGGCCTGCAACTGCTGCGGGAAGAGTTAGCGTTATCGCAGAGAACCGTTGCGGAAGCGATGGGCGTTA
AGCAGCCACGTATCACGCAAATTGAGCAGGGCGGCGCCGATCAGCGTCTGATCACCATTAAGCGCTACATTGAAGCGATG
GGCGGCAAGCTAAGCCTGCTGATTGAAATGCCGGACGGCTCGGGTGGAAGAATTCTGCGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References