Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-UPF0150
Location 1123284..1123843 Replicon chromosome
Accession NZ_CP058315
Organism Treponema parvum strain OMZ 843

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HXT04_RS05010 Protein ID WP_210122188.1
Coordinates 1123658..1123843 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HXT04_RS05005 Protein ID WP_210116635.1
Coordinates 1123284..1123661 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXT04_RS04990 (HXT04_04990) 1118295..1119077 + 783 WP_210122185.1 sulfite exporter TauE/SafE family protein -
HXT04_RS04995 (HXT04_04995) 1119254..1121041 + 1788 WP_210122186.1 flavocytochrome c -
HXT04_RS05000 (HXT04_05000) 1121191..1123116 + 1926 WP_210122187.1 FAD-dependent oxidoreductase -
HXT04_RS05005 (HXT04_05005) 1123284..1123661 - 378 WP_210116635.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HXT04_RS05010 (HXT04_05010) 1123658..1123843 - 186 WP_210122188.1 type II toxin-antitoxin system HicA family toxin Toxin
HXT04_RS05015 (HXT04_05015) 1124141..1125064 + 924 WP_210116633.1 ankyrin repeat domain-containing protein -
HXT04_RS05020 (HXT04_05020) 1125069..1126295 + 1227 WP_210122189.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase -
HXT04_RS05025 (HXT04_05025) 1126288..1126767 + 480 WP_210122190.1 CvpA family protein -
HXT04_RS05030 (HXT04_05030) 1126767..1128131 + 1365 WP_210122191.1 DNA polymerase III -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-56)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-62)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6884.38 Da        Isoelectric Point: 10.6732

>T166541 WP_210122188.1 NZ_CP058315:c1123843-1123658 [Treponema parvum]
MKDKDLLKLLLKDGWEMVAVKGSHHKITKNGKIEIIPVHGKDIKKGLLAAILKRTKLEVDK

Download         Length: 186 bp

>T166541 NZ_CP074349:5250357-5251001 [Pseudomonas cichorii]
ATGAACTACACCAGTCTGAATCCAGAGAAGGCTCTGATTTGGCGTATCGTCCACCGCGATAACCTGCCTTGGATTCTGGA
CAACGGCCTGCATTGCGCCAGTTCGGATGTGCAAGCACCGCAATATGTAAATATTGGTAACGCTGACTTGATCGATAAAC
GCCGATCTCGCGATGTACCAATTGCTCCAATGGGTGTGTTGGCTGACTACGTGCCCTTCTACTTCACCCCCTTCTCTGTG
ATGATGAAAAATATTCATTCCGGGTGGAGCGTTCAGCAGCGCAGCAATGACGAGATTGTGATTCTGGTATCCAGCCTGCA
CCGCGTCGAACAGCTTGGCCTACCGTTCGTCTTCACAAACGCACATGCCTACCCGGATTGGACAAACTATTACAGCGATC
TGGCGCATCTCAGCGAGATCGACTGGCCTATCCTTCAGCGGCGCGACTTCAAACGCGATCCTGATGACCCTCGAAAGATG
GAGCGCTATCAGGCCGAAGCGCTGATTCACCACCACCTACCGATTACAGGACTCCTTGGCATCATGTGCTACACCGATGC
AATGAAAGAACGCATAGAGCAAGACGTGGTCGCTAGAGGCCTGACGTTGTCTGTTCATGCGCGTCCGGGATGGTATTTCC
AATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13843.83 Da        Isoelectric Point: 4.4178

>AT166541 WP_210116635.1 NZ_CP058315:c1123661-1123284 [Treponema parvum]
MKVIYPAIFHGEDGGFWVEFPDLPGCTTQGDSQAETYINAVEAMELFLQDDYTVDTLPAASAANKIKPGKDSFVVFVCGE
YKENEKAVKKTLTIPFWLNVQAEKAGVNFSQTLQEALCKKLNVVM

Download         Length: 378 bp

>AT166541 NZ_CP074349:5250998-5252086 [Pseudomonas cichorii]
ATGATCAGATTCACTCAAGGCAACCTTCTGGAAGCCAAAACCGAAGCCCTCGTCAATACAGTGAATACCGTAGGCGTAAT
GGGCAAAGGTATCGCCCTGATGTTCAAAGAGCGCTTTGCGGAGAATTACCGCCTCTATTCGGCTGCCTGCAAGGCTGGCG
AGGTAGAAACAGGCAAAGTTCACGTGACCGCAGTCAATGAGCTGGAAGGCCCTCGCTGGATCGTAAACTTCCCAACCAAA
CGTCACTGGCGATCCCCTTCGCAGATGCAGTGGATAACCGAAGGCTTACACGATCTACGTCGCTTTTTGATTGAAAACCA
TGTTAAGTCCGTGGCGGTTCCTCCGCTAGGTGCAGGGAACGGTGGCTTGAAATGGCCAGAAGTTCGTGAGCAGATCGTTG
ATGCTTTGAGTGATCTGGACGTCGATGTGCTGGTATTCGAGCCATCCAGTCAGTATCTGAATGTCGCCAAACGTAGCGGA
GTGGAAAAGCTCACGCCTGCTCGCGCACTCATTGCCGAACTGGTTCGACGTTACTGGGTTTTAGGTATGGAATGCAGCCT
GCTTGAGATTCAGAAGCTGGCTTGGTTCTTAGAGCGAGCCATTAAAAATCTGCCGGGCACCAAAAACCCGCTGGATCTCA
AGTTCGTCGCCCATAAATACGGGCCGTATGCCAACCGATTGGAACACCTGCTCGACAATCTGGACGGCAGCTATCTGCAT
TGCGACAAACGCATCAGTGATGCAGATATCAGTGATGTGATCTGGTTTGACCAAGACCGTAAAGCTTTTCTGCAAACCTA
TCTCAAAACAGAAGCTAGGGAGTATTCCCAAGCTCTGGAACTGACCGCCGAACTGATCGATGGCTTTGAGTCACCGTTCG
GCATGGAGCTGTTGGCAACGGTTGATTGGTTGCTCAGTCAGGAAGAAGTTTCCCCAACCGTTCCTACCGTGCGCGAAGCG
TTGCGGCATTGGGATGGCGGAACTGGTGCTGCTGCTCGTAAAAGCAAGCTGTTCGATGATCAGGCGATTGATATTGCGCT
CAAACGGCTTACCTCCAGTAGCTTCAGCTCGGCAGTAGTTAACTGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References