Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 236682..237247 Replicon chromosome
Accession NZ_CP058315
Organism Treponema parvum strain OMZ 843

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HXT04_RS01075 Protein ID WP_210117317.1
Coordinates 236682..237020 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HXT04_RS01080 Protein ID WP_210117316.1
Coordinates 237014..237247 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXT04_RS01055 (HXT04_01055) 232608..234281 - 1674 WP_210121711.1 iron ABC transporter permease -
HXT04_RS01060 (HXT04_01060) 234370..235491 - 1122 WP_210121712.1 ABC transporter ATP-binding protein -
HXT04_RS01065 (HXT04_01065) 235697..235957 - 261 WP_210121713.1 Txe/YoeB family addiction module toxin -
HXT04_RS01070 (HXT04_01070) 235954..236214 - 261 WP_210121714.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
HXT04_RS01075 (HXT04_01075) 236682..237020 - 339 WP_210117317.1 endoribonuclease MazF Toxin
HXT04_RS01080 (HXT04_01080) 237014..237247 - 234 WP_210117316.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HXT04_RS01085 (HXT04_01085) 237476..237988 + 513 WP_210119894.1 ClbS/DfsB family four-helix bundle protein -
HXT04_RS01090 (HXT04_01090) 238224..238382 + 159 WP_256729228.1 hypothetical protein -
HXT04_RS01095 (HXT04_01095) 238366..238713 + 348 WP_257225332.1 hypothetical protein -
HXT04_RS01100 (HXT04_01100) 238680..239339 + 660 WP_210117314.1 MmcQ/YjbR family DNA-binding protein -
HXT04_RS01105 (HXT04_01105) 239426..240484 + 1059 WP_210121715.1 iron ABC transporter permease -
HXT04_RS01110 (HXT04_01110) 240481..241269 + 789 WP_210121716.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 234370..251379 17009


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-110)

Antitoxin

SpoVT-AbrB domain

(7-48)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12861.75 Da        Isoelectric Point: 6.6947

>T166539 WP_210117317.1 NZ_CP058315:c237020-236682 [Treponema parvum]
MVNSNYVPEKGDLVWLDFDPQTGHEQKGRRPAICISHKSYNQKIGLALFCPITSRIKGYPFEIVLNQHSINGCILSDQIK
NLNWKQRNCDFIEKAADEEIDSVVQNIKLMIE

Download         Length: 339 bp

>T166539 NZ_CP074348:527362-527712 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAGAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGATAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8586.90 Da        Isoelectric Point: 7.2020

>AT166539 WP_210117316.1 NZ_CP058315:c237247-237014 [Treponema parvum]
VQTIVHKWGNSLGFRIPSLWAKDNDIKNGSKVEVIIEKGKIVILPQKKSLDDMLALVNEENIHSEVSTGYAVGKEAW

Download         Length: 234 bp

>AT166539 NZ_CP074348:527075-527356 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References