166530

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2279894..2280408 Replicon chromosome
Accession NZ_CP058312
Organism Staphylococcus aureus strain BLR-DV

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag HW113_RS11440 Protein ID WP_000581792.1
Coordinates 2279894..2280103 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag HW113_RS11445 Protein ID WP_000138932.1
Coordinates 2280115..2280408 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW113_RS11420 2275402..2276760 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
HW113_RS11425 2276775..2277845 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
HW113_RS11430 2278163..2279365 + 1203 WP_001109939.1 rod shape-determining protein RodA -
HW113_RS11435 2279629..2279766 - 138 WP_000828354.1 hypothetical protein -
HW113_RS11440 2279894..2280103 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
HW113_RS11445 2280115..2280408 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
HW113_RS11450 2280574..2282058 + 1485 WP_000571549.1 cardiolipin synthase -
HW113_RS11455 2282086..2282733 + 648 WP_001187629.1 HD domain-containing protein -
HW113_RS11460 2283546..2284418 - 873 WP_000725802.1 membrane protein insertase YidC -
HW113_RS11465 2284504..2285145 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T166530 WP_000581792.1 NZ_CP058312:c2280103-2279894 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T166530 NZ_CP074346:1369765-1370265 [Pasteurella atlantica]
ATGCCTAAATATATTGAGGAGCCTTTAGATAAAGCTCACAATCGTAAGAACTTTGATTGTGGAAATGAAGAGCTAAATAC
GTTTCTACGTTGCTATGCTGGTCAATCTCATAAAAAAGGGACAGCTAAAACTTATTTAACCTTAGACAAAGAAACAAAAA
AGATTATAGGCTTTTATTCTATTACATTAACATCTATAGAATATAATCAAATACCTAAATCCTTTCAAAAAGGATTAAGT
CGTCATCAAGTACCGTTATTCATTCTTGCTCGCTTAGGCGTAGATGTTTCGGAGCAAAATAAAGGTATAGGCGGAGTATT
ACTTTATAAGGCAATAGAACGTTGCATTAAGGTTTCTGAAGAAGTCGGAGGAATAGGACTTTTAATTGAGGCTAAGGATG
ATGATGTTGCCAAATGGTATAGTAAATTTGGGGCAATTTCATTGCCTGATAAACCATTGTCTTTAATTTTACCTTTTAGC
ACTATAAAAAACATCAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT166530 WP_000138932.1 NZ_CP058312:c2280408-2280115 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT166530 NZ_CP074346:1369488-1369772 [Pasteurella atlantica]
ATGGCTAGAGCAATAAATACAACAAGTGATAGAATATCTATTCGTATTAGTCGTGATGATAAAGAAATACTACAAAAAGC
AACATTATTATCTAAAACAACGATTACTGATTTTGTCCTTAAACACGTACTATATAATGCTAAAGAGATTGTCAAAGAAC
ACGAGGAGTCATCACTATCAAAGAATGACTTAGCATTTATAATGGACTTGCTTGATAATCCTCCAGCTCCAAATGAACGT
TTAATGAAAGCTGCTAAAACAGCTCAGGATTTATACGATGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References