166528

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2067409..2067886 Replicon chromosome
Accession NZ_CP058312
Organism Staphylococcus aureus strain BLR-DV

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag HW113_RS10405 Protein ID WP_000052078.1
Coordinates 2067698..2067886 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HW113_RS10400 Protein ID WP_001059690.1
Coordinates 2067409..2067669 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW113_RS10365 2062802..2063518 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
HW113_RS10370 2063666..2064088 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
HW113_RS10375 2064487..2064981 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
HW113_RS10380 2065136..2065753 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
HW113_RS10385 2065826..2066407 - 582 WP_001140686.1 phosphoglycerate mutase family protein -
HW113_RS10390 2066632..2066868 + 237 WP_000368687.1 hypothetical protein -
HW113_RS10395 2066865..2067068 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
HW113_RS10400 2067409..2067669 + 261 WP_001059690.1 hypothetical protein Antitoxin
HW113_RS10405 2067698..2067886 + 189 WP_000052078.1 hypothetical protein Toxin
HW113_RS10410 2068074..2068643 + 570 WP_001106654.1 hypothetical protein -
HW113_RS10415 2068731..2069015 + 285 WP_001004395.1 hypothetical protein -
HW113_RS10420 2069077..2069295 + 219 WP_000005886.1 hypothetical protein -
HW113_RS10425 2069791..2069991 - 201 WP_001059082.1 cold-shock protein -
HW113_RS10430 2070348..2071034 - 687 WP_177548856.1 thermonuclease family protein -
HW113_RS10435 2071375..2071845 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T166528 WP_000052078.1 NZ_CP058312:2067698-2067886 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T166528 NZ_CP074346:c1295740-1295486 [Pasteurella atlantica]
ATGATTGTCTGTTTTACTGACAAAGGTTGGGAAGATTATCTTTATTGGCAAGAGACTGATAAAAAAACCTTAAAACGAAT
TAATTCTTTGATAAAAGAAATCAAGCGAAGCCCTTTTATAGGTAAAGGGAAGCCAGAACCATTAAAACATTCTTTAAGTG
GTTTTTGGTCAAGACGAATAACGGAGGAACATAGATTGGTTTATCGGGTATCTGAGGATGCTTTATCTATTGTTGCCTGT
CGCTATCACTATTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT166528 WP_001059690.1 NZ_CP058312:2067409-2067669 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT166528 NZ_CP074346:c1295988-1295737 [Pasteurella atlantica]
ATGCAAGTAATGACCTATACTGAAGCTCGTCAAAATCTAGCACAAACAATGACAGCAACAGCAGAAAATTGTGAGCCAGT
GCTTATTACAAGAAGTAACAATGAAAGTTGTGTTCTTATTTCTTTACGTGAATATGAAGCATTAGAAGAAACAGCCTATC
TTTTACGCTCACCAGCAAATGCTAAGCATTTATTGGAAAGTATTGAAGAGCTAAAATTAGGTAATGTTACTAAAAGAGAA
TTGATTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References