Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3493615..3494233 Replicon chromosome
Accession NZ_CP058308
Organism Escherichia coli strain AMSCJX04

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HXS78_RS16770 Protein ID WP_001291435.1
Coordinates 3494015..3494233 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HXS78_RS16765 Protein ID WP_000344800.1
Coordinates 3493615..3493989 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXS78_RS16755 3488704..3489897 + 1194 WP_177754084.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HXS78_RS16760 3489920..3493069 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
HXS78_RS16765 3493615..3493989 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HXS78_RS16770 3494015..3494233 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HXS78_RS16775 3494405..3494956 + 552 WP_000102568.1 maltose O-acetyltransferase -
HXS78_RS16780 3495072..3495542 + 471 WP_000136192.1 YlaC family protein -
HXS78_RS16785 3495706..3497256 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HXS78_RS16790 3497298..3497651 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HXS78_RS16800 3498030..3498341 + 312 WP_000409911.1 MGMT family protein -
HXS78_RS16805 3498372..3498944 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T166505 WP_001291435.1 NZ_CP058308:3494015-3494233 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T166505 NZ_CP074182:840401-840811 [Raoultella planticola]
GTGGTCCTGTGGCAATCTGATTTACGCATTTCCTGGCGCTCGCAGTGGTTCTCGCTGCTGCTGCACGGCATTGTGGCGGC
GATTGTCCTGCTGATGCCCTGGCCGCTGAGCTACACACCGCTATGGCTATTGCTGCTGTCGCTGGTGGTGTTCGACAGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCGGGGGGAAATAAAGCTGATGACCGATTCGCGTTTGCGTTGGCAAAAAGCG
GAATGGGAAATTGTCGGCACGCCGTGGGTGATTAATAGCGGGATGTTGCTGCGCCTGCAGGATATGCAAACGCGTCGCCG
CCAGCATCTGTGGGTCGCTGCAGACAGTATGGACGCCAAAGAGTGGCGAGATCTGCGCCGGTTGGTTTTACAAAAACCGG
CACAGGATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT166505 WP_000344800.1 NZ_CP058308:3493615-3493989 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT166505 NZ_CP074182:840154-840420 [Raoultella planticola]
ATGGACATTACGAATAAAGCCCGCATCCACTGGGCATGCCGCAGGGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTCGAGTATGAATACGATACGCTCAGCGATGAAGACAAACAGCTGTTTATCCGTCTGTTAGAAAACGACGATCCGGACC
TGTTTAACTGGCTGATGAATCATGGCGAACCGGCTGATGCACAACTGCAACGGATGGTAAAATTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References