Detailed information of TA system TA166502

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2436192..2437780
• Replicon: chromosome
• Accession: NZ_CP058308
• Organism: Escherichia coli strain AMSCJX04

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: U9XU38
• Locus tag: HXS78_RS11750
• Protein ID: WP_001125455.1
• Coordinates: 2436458..2437780 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HXS78_RS11745
• Protein ID: WP_001296726.1
• Coordinates: 2436192..2436458 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HXS78_RS11745	2436192..2436458	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HXS78_RS11750	2436458..2437780	+	1323	WP_001125455.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
HXS78_RS11755	2438092..2438300	+	209	Protein_2298	helix-turn-helix transcriptional regulator	-
HXS78_RS11760	2438734..2439297	+	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
HXS78_RS11765	2439658..2440368	+	711	WP_001195166.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimA	2436192..2452281	16089

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49321.93 Da
• Isoelectric Point: 8.8753

>T166502 WP_001125455.1 NZ_CP058308:2436458-2437780 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T166502 NZ_CP074179:c193885-193580 [Enterobacter asburiae]
ATGCAGTTCAGGGTTTACACATATAAAAGAGAGAGTCGCTACCGTCTGTTCGTGGATGTGCAGAGTGATATTGTTGATAC
CCCGGGACGGCGAATGGTGATCCCGCTGGCCAGTGCCCGCCTGCTGTCGGACAAGGTCTCCCGCGAACTCTATCCGGTGG
TGCACATCGGGGACGACAGCTACCGGCTGATGACCACTGATATGGCCAGCGTCACCGCAGCCGTTACCGGCGAGGAGGTG
GCCGATCTCAGCCACAGGGAGAATGAGATCAAGAACGCGATTAACCTGATGTTCTGGGGGGTATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT166502 WP_001296726.1 NZ_CP058308:2436192-2436458 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT166502 NZ_CP074179:c194105-193887 [Enterobacter asburiae]
ATGAAGCAGCGTATAACTGTCACCATAGACAGCGACAGTTACCGGTTACTGAAATCCGCGGACGTCAATATCTCGGGTCT
GGTGAATACCGCCATGCAGAACGAAGCCCGACGTCTTCGTGCAGAACGCTGGCAGACTGAAAACCAGGAAGGGATGGCTG
AGGTTGCCCGGTTTATCGAAACGAACGGCTCGTTTGCCGACGAAAACAGGGACTGGTGA

Structures

Toxin

• AlphaFold DB: U9XU38