Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1908686..1909454 Replicon chromosome
Accession NZ_CP058308
Organism Escherichia coli strain AMSCJX04

Toxin (Protein)


Gene name yeeV Uniprot ID A0A6C9I6Z5
Locus tag HXS78_RS09130 Protein ID WP_001563930.1
Coordinates 1908686..1909060 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3W4SUB1
Locus tag HXS78_RS09135 Protein ID WP_044863316.1
Coordinates 1909149..1909454 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXS78_RS09090 1904082..1905248 + 1167 WP_001563931.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
HXS78_RS09095 1905367..1905840 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
HXS78_RS09100 1906038..1907096 + 1059 WP_078267987.1 FUSC family protein -
HXS78_RS09105 1907268..1907597 + 330 WP_000450409.1 DUF496 family protein -
HXS78_RS09110 1907698..1907880 - 183 WP_001016348.1 hypothetical protein -
HXS78_RS09115 1907952..1908080 + 129 Protein_1781 transposase domain-containing protein -
HXS78_RS09120 1908369..1908482 - 114 WP_001161660.1 DUF957 domain-containing protein -
HXS78_RS09125 1908495..1908689 - 195 WP_000988600.1 hypothetical protein -
HXS78_RS09130 1908686..1909060 - 375 WP_001563930.1 type IV toxin-antitoxin system toxin CbtA Toxin
HXS78_RS09135 1909149..1909454 - 306 WP_044863316.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HXS78_RS09140 1909591..1909812 - 222 WP_000692323.1 DUF987 domain-containing protein -
HXS78_RS09145 1909875..1910351 - 477 WP_023910200.1 RadC family protein -
HXS78_RS09150 1910367..1910852 - 486 WP_000214393.1 antirestriction protein -
HXS78_RS09155 1910943..1911761 - 819 WP_023910202.1 DUF945 domain-containing protein -
HXS78_RS09160 1911861..1912094 - 234 WP_001119729.1 DUF905 family protein -
HXS78_RS09165 1912173..1912628 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(2-96)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13883.97 Da        Isoelectric Point: 7.8522

>T166493 WP_001563930.1 NZ_CP058308:c1909060-1908686 [Escherichia coli]
MKTLPVLPGLAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T166493 NZ_CP074177:c1646469-1646092 [Enterobacter asburiae]
ATGCAAACCTTATCCGCCATTCCGACTCGGAAGGCATCGTCACGCCCAACGCCCGTTGAAATCTGGCAGCGACTTCTTAC
GTATCTGCTGGAAAGGCATTACGGCCTTTCGCTTAACGACACACAGTTTGGTGATGGCAATGTGATTCAGCAATATATTG
ACGCCGGGATTTCACTGGCAGATGCACTCAATTTTCTCGTTGAAAAATCTGAACTGGTACGAATTGATCGCCCTGGTTTC
TCCATTCAGCATCAGTCTCCGTTCATCAGCACTATTGACATACTCCAGGCCAGAAAGGCCATCGGCCTGATGCAACGTAC
CGGCTATAAAGCGGTGACTTGCGCCATCAGTGGACGCTCTTCCGGAGGGCTGCAATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11250.00 Da        Isoelectric Point: 7.2621

>AT166493 WP_044863316.1 NZ_CP058308:c1909454-1909149 [Escherichia coli]
MPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPRHQHTVTLYAKGLTCKA
DTLSSCGYVYLAVYPTPEMKN

Download         Length: 306 bp

>AT166493 NZ_CP074177:c1646891-1646526 [Enterobacter asburiae]
TTGTCAAATAACACACCGCCAGCCAACCATGATATTGCCGAACCCTGGTGGGGACTAAAACCCGCTGTCATGCCATGCTT
TGGCGCACGACTGGTACAGGAAGGCAACCACCTGCATTATCTGGCTGACCGCAGCACTATCGAAGGAACATTCAGCGATG
CGGACTTACGCCATCTTGACCAGGCGTTTCCACTATTACTGAAGCAGCTTGAGCTGATGCTCACCAGCGGTGAACTCAAT
CCCCGCCATCAGCACAGCGTCACGCTGTATGCAAAAGGGCTGACCTGTGATGCAGATACACTGGGCAGTTGTGGTTACCT
TTATATCGCGATTTATCCGACGTCAGGCAACAGCATCCTCCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C9I6Z5

Antitoxin

Source ID Structure
AlphaFold DB A0A3W4SUB1

References