Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 790949..791747 Replicon chromosome
Accession NZ_CP058308
Organism Escherichia coli strain AMSCJX04

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag HXS78_RS03805 Protein ID WP_000854735.1
Coordinates 790949..791326 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag HXS78_RS03810 Protein ID WP_032153712.1
Coordinates 791373..791747 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXS78_RS03770 786512..787690 + 1179 WP_000094989.1 type II secretion system protein GspL -
HXS78_RS03775 787692..788228 + 537 WP_000942795.1 GspM family type II secretion system protein YghD -
HXS78_RS03780 788643..788969 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
HXS78_RS03785 788966..789229 - 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
HXS78_RS03790 789301..790167 - 867 WP_032153714.1 DUF4942 domain-containing protein -
HXS78_RS03795 790252..790449 - 198 WP_000839265.1 DUF957 domain-containing protein -
HXS78_RS03800 790461..790952 - 492 WP_023155722.1 hypothetical protein -
HXS78_RS03805 790949..791326 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
HXS78_RS03810 791373..791747 - 375 WP_032153712.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HXS78_RS03815 791827..792048 - 222 WP_000692345.1 DUF987 domain-containing protein -
HXS78_RS03820 792117..792593 - 477 WP_001186715.1 RadC family protein -
HXS78_RS03825 792609..793094 - 486 WP_032153711.1 antirestriction protein -
HXS78_RS03830 793186..794004 - 819 WP_001234693.1 DUF945 domain-containing protein -
HXS78_RS03835 794095..794304 - 210 WP_023155727.1 DUF905 family protein -
HXS78_RS03840 794334..795011 - 678 WP_023155728.1 hypothetical protein -
HXS78_RS03845 795130..796014 - 885 WP_024166630.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR papI / papB 788966..856124 67158


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T166488 WP_000854735.1 NZ_CP058308:c791326-790949 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T166488 NZ_CP074177:c289617-289207 [Enterobacter asburiae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTTTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCAGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTGTTGCAACAAACGA
CGCAGGGGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT166488 WP_032153712.1 NZ_CP058308:c791747-791373 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT166488 NZ_CP074177:c289864-289598 [Enterobacter asburiae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTTGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAATCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References