Detailed information of TA system TA166481

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 576706..577293
• Replicon: chromosome
• Accession: NZ_CP058307
• Organism: Avibacterium paragallinarum strain AVPG2015

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: VY92_RS02960
• Protein ID: WP_103846679.1
• Coordinates: 577030..577293 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3G8W4K1
• Locus tag: VY92_RS02955
• Protein ID: WP_035686016.1
• Coordinates: 576706..576996 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VY92_RS02930	571913..573025	+	1113	WP_035685801.1	porin	-
VY92_RS02935	573298..574365	+	1068	WP_046097416.1	porin	-
VY92_RS02940	574588..574770	+	183	WP_124994837.1	hypothetical protein	-
VY92_RS02945	574715..575668	+	954	WP_124994836.1	porin	-
VY92_RS02950	575789..576514	-	726	WP_035685795.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
VY92_RS02955	576706..576996	+	291	WP_035686016.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
VY92_RS02960	577030..577293	+	264	WP_103846679.1	type II toxin-antitoxin system YafQ family toxin	Toxin
VY92_RS02965	577382..579160	+	1779	WP_035685792.1	aspartate--tRNA ligase	-
VY92_RS02970	579286..579729	+	444	WP_035685789.1	dihydroneopterin triphosphate diphosphatase	-
VY92_RS02975	580183..580923	+	741	WP_035685786.1	YebC/PmpR family DNA-binding transcriptional regulator	-
VY92_RS02980	580999..581559	+	561	WP_035685784.1	crossover junction endodeoxyribonuclease RuvC	-
VY92_RS02985	581647..582261	+	615	WP_046097415.1	Holliday junction branch migration protein RuvA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-71)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10200.10 Da
• Isoelectric Point: 9.1425

>T166481 WP_103846679.1 NZ_CP058307:577030-577293 [Avibacterium paragallinarum]
MAKEFKRDLVQLAKKAPHLFVHPRYLEVMHCLTNGLTLPAEYKNHPLKNNLKGYMDCHILNDLVLIYKIEQQCLKLVRLN
THSEVFA

Nucleotide

• Length: 264 bp

>T166481 NZ_CP074171:112663-112938 [Enterobacter sp. JBIWA003]
TTGTCGAAGTGGAATATTAAGTTCACCAGGAACGGAGCTGATGACCTTAGCTACTGGCGTGATACTGACAAAAAGAAGTT
TGAGCGTATCCGGCAGCTGTTGCGCAGCATCGAGGCTGATCCGCTGACAGGTATCGGAAAACCCGAACGGCTGCGGCACC
ACAAAGATCCGGCGCTCTATTCCCGCCGGATTGATCAGAGTCACCGTCTGGTCTATTCAATCAAGAGCGGAGAAATCATC
ATCTACGCAGCCCGTTATCACTATGGTGACAAATAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10716.23 Da
• Isoelectric Point: 4.7185

>AT166481 WP_035686016.1 NZ_CP058307:576706-576996 [Avibacterium paragallinarum]
MTNNNAVVNFRLPQHLKTEAFEVIAQYGLTPSQVFNMFLTEIATTKAIPLSLNYLQPNAKTLAAMNEIESGTAERFSLDD
KTDLATLLQQIAEEKK

Nucleotide

• Length: 291 bp

>AT166481 NZ_CP074171:112437-112682 [Enterobacter sp. JBIWA003]
ATGCATGCAATCAATTTTACTGATGCCCGTAAACATTTTGCTGACACCATGAAGCGCGTCACTGATGATGCTGAACCTGT
ACGCGTCATGCGTCGTGACGCACCTGATATTGTTATGATCGATGCAGGAGAGTATGAGGCGCTAATCGAAACGGTCTATC
TGTTCAGCAATCCGGCGAACGCCGCGCATATCAATGAGTCAATGAAACAGGCGGAGCGCGGCGAATTTGTCGAAGTGGAA
TATTAA

Structures

Antitoxin

• AlphaFold DB: A0A3G8W4K1