Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3537723..3538341 Replicon chromosome
Accession NZ_CP058302
Organism Escherichia coli strain AH65

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HUU85_RS16855 Protein ID WP_001291435.1
Coordinates 3537723..3537941 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HUU85_RS16860 Protein ID WP_000344800.1
Coordinates 3537967..3538341 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUU85_RS16820 3533012..3533584 + 573 WP_000779831.1 YbaY family lipoprotein -
HUU85_RS16825 3533615..3533926 - 312 WP_000409911.1 MGMT family protein -
HUU85_RS16835 3534305..3534658 + 354 WP_042017122.1 DUF1428 family protein -
HUU85_RS16840 3534700..3536250 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HUU85_RS16845 3536414..3536884 - 471 WP_000136192.1 YlaC family protein -
HUU85_RS16850 3537000..3537551 - 552 WP_000102564.1 maltose O-acetyltransferase -
HUU85_RS16855 3537723..3537941 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HUU85_RS16860 3537967..3538341 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HUU85_RS16865 3538887..3542036 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
HUU85_RS16870 3542059..3543252 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T166456 WP_001291435.1 NZ_CP058302:c3537941-3537723 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T166456 NZ_CP074162:8707-8997 [Enterobacter sp. JBIWA005]
ATGCCATCGTTAAGCTGGACACCACAGGCGCTGGCCGACGTTCAGCGCCTGTATCGTTTTCTGGCTCCCCGGGATCTGAA
TGCCGCCCGTAACGCCATCACTGAGATTCGAAACAGCGTCAAAATACTGGCGTATCAGCCTGAGTCCGGACGACCGATAG
AAGAATCGCCATCCTACCGGGAATGGCCGATAAGCTTCGGTAACAGTGGCTATGTGGCGCTTTACCGTATTGAAGATGAC
GCCGTGACCATCCTTGCAGTTCGTCATCAGCGGGAAGCCGACTGGTCGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT166456 WP_000344800.1 NZ_CP058302:c3538341-3537967 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT166456 NZ_CP074162:8441-8719 [Enterobacter sp. JBIWA005]
ATGGCAACAGCCACATCAATCAAGCTCGATGACGATCTGAAAAACCGTCTTCAACATCTGGCGGAGTCCCGCCGCCGTTC
TGCACACTGGATCATGCGTGAAGCCATTACGCAGTACGTTGAACGGGAAGAAAAACGCGAAGCGTACTTACGTGATGCGC
AAAATGCCTGGGAAGAATTCCAGCGCACCGGGCTGCATATCACCGCAGAAGAAGCAGATGAATGGCTGGCACAACTGGCC
GCGGGTAACGACGTGGAGCCGCCTGAATGCCATCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References