Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 1543988..1545191 Replicon chromosome
Accession NZ_CP058281
Organism Helicobacter pylori strain Hk711

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag HWU15_RS07390 Protein ID WP_237015422.1
Coordinates 1543988..1544764 (-) Length 259 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag HWU15_RS07395 Protein ID WP_237015423.1
Coordinates 1544754..1545191 (-) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWU15_RS07380 1541332..1542493 + 1162 Protein_1437 aminotransferase class V-fold PLP-dependent enzyme -
HWU15_RS07385 1542575..1543762 + 1188 WP_237015421.1 transcription termination factor NusA -
HWU15_RS07390 1543988..1544764 - 777 WP_237015422.1 hypothetical protein Toxin
HWU15_RS07395 1544754..1545191 - 438 WP_237015423.1 Panacea domain-containing protein Antitoxin
HWU15_RS07400 1545416..1546783 - 1368 WP_237015424.1 RNA-directed DNA polymerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(24-119)


Sequences

Toxin        


Download         Length: 259 a.a.        Molecular weight: 30259.44 Da        Isoelectric Point: 8.3803

>T166431 WP_237015422.1 NZ_CP058281:c1544764-1543988 [Helicobacter pylori]
METKEEDKDKKLEEIIVLLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTKDKEQAFMMLTQNIKTLKEIQ
DNREVENIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIRLDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFVG
GLAFSTSVLSNIDKVNAYRLVFVMAFIALFFGNILYLLFSFLSKISLSSKISLSKEEKDKQENFKKPIFWFNLMVTILFV
IGFFGELHIIQRLVSKYL

Download         Length: 777 bp

>T166431 NZ_CP074151:20208-20519 [Enterobacter sp. JBIWA008]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGCTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCGAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTGAGGGTTATCGCCTATATCAATTTCGTGAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 17242.38 Da        Isoelectric Point: 6.4976

>AT166431 WP_237015423.1 NZ_CP058281:c1545191-1544754 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQSLREDELEAINRSIKKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Download         Length: 438 bp

>AT166431 NZ_CP074151:20516-20935 [Enterobacter sp. JBIWA008]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCGGCTGTCCCCTTCCTGGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGATTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATCGCTGAAATGCCAGTC
GGCGTTGCACTTCTGCGTACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCGCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References