Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 937911..938742 Replicon chromosome
Accession NZ_CP058281
Organism Helicobacter pylori strain Hk711

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HWU15_RS08075 Protein ID WP_272904289.1
Coordinates 937911..938384 (-) Length 158 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HWU15_RS04450 Protein ID WP_237015057.1
Coordinates 938365..938742 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWU15_RS04425 934759..935526 - 768 WP_237015054.1 ABC transporter ATP-binding protein -
HWU15_RS04430 935526..936506 - 981 WP_000921438.1 iron ABC transporter permease -
HWU15_RS04435 936499..937347 - 849 WP_237015055.1 SDR family oxidoreductase -
HWU15_RS04440 937487..938011 + 525 WP_237015056.1 acyl-CoA thioesterase -
HWU15_RS08075 937911..938384 - 474 WP_272904289.1 YafQ family addiction module toxin Toxin
HWU15_RS04450 938365..938742 - 378 WP_237015057.1 hypothetical protein Antitoxin
HWU15_RS04455 939577..941817 - 2241 WP_237015058.1 Hop family adhesin BabA -
HWU15_RS04470 942235..942852 + 618 WP_237015059.1 helicase DnaB modulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 18037.41 Da        Isoelectric Point: 10.6377

>T166430 WP_272904289.1 NZ_CP058281:c938384-937911 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFKDHALKGKWKPFRECHIKADILLVYLVKDDELISLR
LGSHSELFCKSPAQLKRFKLTAHQTTPSLGIKFRVKTPPTRFLLFTCPRVSRFSNTLVCAFPCVSKPLHNGGFQPLF

Download         Length: 474 bp

>T166430 NZ_CP074149:c3967347-3966937 [Enterobacter sp. JBIWA008]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CATTGTGTTACTGATGCCATGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTCTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATCAATGCACGTCAGGGAGAGATTAAATTGCTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGTAAGGTGGATGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGATCTGCGCCGGATGTTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14525.57 Da        Isoelectric Point: 8.7066

>AT166430 WP_237015057.1 NZ_CP058281:c938742-938365 [Helicobacter pylori]
MPNSPTKKDCTQYSEKQLFNLINQLERKIKKMQNDRASFREKMAKELEKRDQNFKDKIDALNELLQKISQAFDGKRGCCL
GHEIPNLETQQAMKDALNKEIDLIVEDFSGYSDERKRALGVKTQS

Download         Length: 378 bp

>AT166430 NZ_CP074149:c3967594-3967328 [Enterobacter sp. JBIWA008]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACACCTTAAGCGACGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAATCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References