Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 510381..510886 Replicon chromosome
Accession NZ_CP058259
Organism Actinomyces sp. oral taxon 169 strain F0496

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1Q8HWJ3
Locus tag HW274_RS02155 Protein ID WP_075253511.1
Coordinates 510632..510886 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1Q8HWK9
Locus tag HW274_RS02150 Protein ID WP_075253512.1
Coordinates 510381..510632 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW274_RS02120 505472..505744 + 273 WP_185989094.1 ribbon-helix-helix protein, CopG family -
HW274_RS02125 505731..506021 + 291 WP_185989095.1 toxin -
HW274_RS02130 506319..506606 + 288 WP_009395767.1 helix-turn-helix domain-containing protein -
HW274_RS02135 506951..508555 + 1605 WP_185989096.1 Na+/H+ antiporter -
HW274_RS02140 508625..509485 - 861 WP_185989097.1 glycoside hydrolase family 16 protein -
HW274_RS02145 509803..510207 - 405 Protein_414 HigA family addiction module antidote protein -
HW274_RS02150 510381..510632 + 252 WP_075253512.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HW274_RS02155 510632..510886 + 255 WP_075253511.1 Txe/YoeB family addiction module toxin Toxin
HW274_RS02160 511352..514093 - 2742 WP_075253510.1 exo-alpha-sialidase -
HW274_RS02165 514331..515551 - 1221 WP_075253509.1 homoserine O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9900.36 Da        Isoelectric Point: 9.9487

>T166423 WP_075253511.1 NZ_CP058259:510632-510886 [Actinomyces sp. oral taxon 169]
MRLVWDPYAWEDYTHWQKADRRILKRVNTLIDAALRDPFGGIGKPGRLKYGASGAWSRRITDEHRLVYLVAGDDLVILQV
RYHY

Download         Length: 255 bp

>T166423 NZ_CP074149:c83583-83206 [Enterobacter sp. JBIWA008]
ATGCAAACCTTATCCGCCATTTCGGTGCGGAAGGCGTCGTCACGCCCGACGCCCGTTAAAATCTGGCAGCAACTTCTTAC
GTATCTGCTGGAAAGGCATTACGGCCTTTCGCTTAACGACACGCAGTTTGGCAACGACTGTGTCATACAGCAGCATATTG
ACGCCGGAATTTCACTGGCAGATGCACTCAATTTTCTCGTTGAAAAATCTGAACTGGTACGAATTGATCGCCCCGGTTTC
TCCATTCAGCATCAGTCCCCTTTTATCGGAGTGATTGATATTCTCCGGGCCAGAAAGGCCACCGGTCTGATGCAACGTAC
TGGCTATAAAGCGGTGACTTGCGCCATCAGTGGACAGTCTTCCAGGGAGCAGCAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9436.45 Da        Isoelectric Point: 4.6509

>AT166423 WP_075253512.1 NZ_CP058259:510381-510632 [Actinomyces sp. oral taxon 169]
MSISASEARKTLYPLIERVNADHDAVEIVSRKGSAVLMPADEYAAWQETAYLFRSPENARRLLDAYDRARAGHTEMHDLD
QED

Download         Length: 252 bp

>AT166423 NZ_CP074149:c84005-83640 [Enterobacter sp. JBIWA008]
ATGCAGAACACAACAAATGTAGCAAACCATGATATTGCCGAACCCTGGTGGGGACTAAAACCCACCGTCACGCCGTGTTT
TGGTGCGCGGCTGGTACAGGAGGGCAACCGGCTGCACTATCTCGCCGACCGCGCCAGTATTATCGGACAGTTCAGCGACG
CGGATTTACGCCATCTCGATCAGGCGTTTCCGGTGCTACTCAAACAGCTGGAATTAATGCTGGTTTCCGGTGAACTCAAT
CCCCGCCATCAGCACTGCGTCACGCTGTATGGGAAAGGGCTGACCTGCGATGCCGATACACTGGGCAGTTGTGGTTACCT
TTATATCGCAATTTATCCGACGTCAGCCAACAGCATCCCCCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q8HWJ3

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8HWK9

References