Detailed information of TA system TA166422

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 417839..418410
• Replicon: chromosome
• Accession: NZ_CP058259
• Organism: Actinomyces sp. oral taxon 169 strain F0496

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HW274_RS01740
• Protein ID: WP_185989070.1
• Coordinates: 417839..418216 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HW274_RS01745
• Protein ID: WP_185989071.1
• Coordinates: 418213..418410 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HW274_RS01725	413424..415271	+	1848	WP_185989067.1	phosphoenolpyruvate carboxykinase (GTP)	-
HW274_RS01730	415914..417164	+	1251	WP_185989068.1	hypothetical protein	-
HW274_RS01735	417152..417757	-	606	WP_185989069.1	hypothetical protein	-
HW274_RS01740	417839..418216	-	378	WP_185989070.1	type II toxin-antitoxin system VapC family toxin	Toxin
HW274_RS01745	418213..418410	-	198	WP_185989071.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
HW274_RS01750	418621..419448	+	828	WP_185989072.1	AraC family transcriptional regulator	-
HW274_RS01755	419587..420363	+	777	WP_185989073.1	VOC family protein	-
HW274_RS01760	420595..421806	+	1212	WP_185989074.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-113)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (2-42)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13768.82 Da
• Isoelectric Point: 6.4937

>T166422 WP_185989070.1 NZ_CP058259:c418216-417839 [Actinomyces sp. oral taxon 169]
VILVDTSVWIDHFHHSDPVLVSLLHEDEIGSHPLVTEELAMGSLRARNDVLKHLAHLRQFPVLSHDELLTLVAAHALWGR
GLSPVDAHLLGSAMLVPGARLWTRDKRLLRAAEERGVSFVEGTAG

Nucleotide

• Length: 378 bp

>T166422 NZ_CP074148:71579-71866 [Serratia sp. JSRIV001]
ATGACTTATAAGATTGACTTTGACAATGCAGCCTTCAAAGAATGGAAAAAATTAGGTGAGACTGTACGTCAACAGTTAAA
AAAGAAGCTGGCACAGATTGTTGAGGCGCCACGCGTTGAGGCTAACCGACTGCACTCTTTACCTGATTGCTATAAGATCA
AACTCCGCGCATCCGGTTATCGGCTGGTTTACAAGGTCGAAGATGAAACGGTTGTGATCCTCGTCCTTGCTGTAGGTAAA
CGCGAACGGCTGGAAGTTTACAAAGCAGCCGCCACAAGGTTGGGTTAG

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 6963.83 Da
• Isoelectric Point: 11.5457

>AT166422 WP_185989071.1 NZ_CP058259:c418410-418213 [Actinomyces sp. oral taxon 169]
VRTTVTLSDDLIANAQELTGITERTELLRAGLETLVRVESARRLAALGGSDRTASAAPRRRTASQ

Nucleotide

• Length: 198 bp

>AT166422 NZ_CP074148:71347-71589 [Serratia sp. JSRIV001]
ATGGGCACAATGAATATTCGTATCGACGATGACTTAAAGGCCCGGGCCGGGGTAGCGCTCGACGGATTGGGGATCACAGC
CTCGGAAGCTGTACGTCTGGTGCTTGAATACGTTGCACAAAATAACCGCCTTCCGGTTCAGGTGGCATTACTGGCTGATG
AAGACGCAGATATCATCGAGCTGGCGCGTGAACGTCTGGCTAATCCTGGCAAACGGATCCGAGTAACACTCGATGACTTA
TAA