Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 5210679..5211315 Replicon chromosome
Accession NZ_CP058255
Organism Priestia megaterium strain BHS1

Toxin (Protein)


Gene name mazF Uniprot ID D5DWT4
Locus tag HW369_RS27050 Protein ID WP_013055004.1
Coordinates 5210679..5211029 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID D5DWT3
Locus tag HW369_RS27055 Protein ID WP_013055003.1
Coordinates 5211034..5211315 (-) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW369_RS27015 5206261..5207055 - 795 WP_013055011.1 RNA polymerase sigma factor SigB -
HW369_RS27020 5207021..5207506 - 486 WP_013055010.1 anti-sigma B factor RsbW -
HW369_RS27025 5207503..5207835 - 333 WP_013055009.1 anti-sigma factor antagonist -
HW369_RS27030 5207895..5208905 - 1011 WP_195695590.1 PP2C family protein-serine/threonine phosphatase -
HW369_RS27035 5208919..5209320 - 402 WP_013055007.1 anti-sigma regulatory factor -
HW369_RS27040 5209324..5209680 - 357 WP_013055006.1 STAS domain-containing protein -
HW369_RS27045 5209683..5210519 - 837 WP_013055005.1 STAS domain-containing protein -
HW369_RS27050 5210679..5211029 - 351 WP_013055004.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
HW369_RS27055 5211034..5211315 - 282 WP_013055003.1 hypothetical protein Antitoxin
HW369_RS27060 5211516..5212706 - 1191 WP_195695591.1 alanine racemase -
HW369_RS27065 5212820..5213878 - 1059 WP_013055001.1 outer membrane lipoprotein carrier protein LolA -
HW369_RS27070 5213937..5214302 - 366 WP_025753519.1 holo-ACP synthase -
HW369_RS27075 5214367..5214969 + 603 WP_195695592.1 rhomboid family intramembrane serine protease -
HW369_RS27080 5214978..5215949 - 972 WP_195695593.1 UV DNA damage repair endonuclease UvsE -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-110)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12991.96 Da        Isoelectric Point: 4.8781

>T166421 WP_013055004.1 NZ_CP058255:c5211029-5210679 [Priestia megaterium]
MVVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVDEALQISVGLIDF

Download         Length: 351 bp

>T166421 NZ_CP074147:c5883171-5881852 [Serratia sp. JSRIV001]
ATGGCTGACCTAGATGTCTACATGAATGGTTATAAGGTAGGGATTTTCAGCCGTGAGGGCACTGGCGCCCATATGTTCCA
ATACGTGGACACTTGGCTTAACCAACCTGGAAGCCGTCCTATATCGCTCTCCATGCCCTTGAGGCGACGGCCTTACAAAG
GGGCAGAAGTCTACAACTTCTTCGATAACCTGCTGCCGGACAACCCTGAGATCCGGGGCAGGATCCTAGCCCGCTACCGT
GCTGACTCGACTCAACCCTTCGACCTTTTGGCACGTATCGGTGCTGACACCATTGGTGCACTGCAACTCTTGCCACAAAA
TGCAGGCCCGGGGGACATTCGCACCATAAACTATAAAGCGCTATCCAACCAAGAACTGGCAAGCATACTTACAGGCTACA
AAGCTGGTGCCCCTCTGGGCATGATTGAGGATGTTGAAGATTTCCGAATTTCCCTGGCCGGGGCCCAAGAAAAGACGGCT
CTCCTCTATCTCGAAAACCGTTGGTGTTTACCGATCGCAGCCACACCAACCACCCATATCATTAAGCTACCCATCGGAAA
AATAGAAAGCCACTCAAACAGTATCGACTTGTCAGACAGTGTCGAAAACGAGTATCTCTGCGCTCTAGTGGCCAAGGAAT
TTGGATTATCAGTCCCCCATTGCTTCATTATGCAAGTGGGTGACATAAAAGCCTTAGCAGTGGAACGCTTTGACCGCCGG
TATGCCTCGGACGGCAGTTGGATCATGCGACTGCCCCAAGAAGATTTCTGCCAGGTTTTAAATGTTCCCTCGGCACGTAA
ATACGAAAATCAGGGTGGTCCAGGGATAAGCGAGATCATGGAATATCTGCTTGGCTCGGTGACAGCGGAAAAGGATCGCT
ATAACTTCATGAAGGCACAGGTATTGTTCTGGTTGTTAGCCGCAACCGATGGACATGCAAAGAACTTCTCGGTGTTCATT
GAAGCTGATGGGCGTTTTCGTTTAACCCCCTTGTACGACATTCTATCTGTCTACCCGGTGTTTGCTGGCAGAGGCCTTCA
TCCGAAAGATGCCAAGCTCGCTATGGGCCTAAAAGGAAGCAAGGGAAAGAAGTACGCCATTGAGCAAATATTCCCACGCC
ACTTCTTCCACACAGCCAAAGCAGTGGGATTTGAGCGCGCCGCCATGGAGGGGATCCTGACGGAATTGGCTGAATCCGTT
GATACCGTCATCGAGCGGGTAACACAGCTGTTGCCAGCAGGTTTTCCTCCCGCCATCAGTAACGCCATTTTAAAGGGCCT
AAAAGCTCGTTCCGCAAGGCTGACAGTGGGCTGGGATTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10691.22 Da        Isoelectric Point: 8.5339

>AT166421 WP_013055003.1 NZ_CP058255:c5211315-5211034 [Priestia megaterium]
VSEASATTEILVRLPKNLVSELDLMVKQENGNRSDFIHQATKLYLRERKKRHIRESMRRGYMEMAKINLNIASEAFLAEY
EADHTVDRLVSGG

Download         Length: 282 bp

>AT166421 NZ_CP074147:c5883431-5883171 [Serratia sp. JSRIV001]
ATGAAGATCACCAATGCCAAGCAGCTCAGCATCTACTTGCGAGATGTCCGCCTCGCAGAGAATCTTTCACAAGAAAAAGT
AGCCAGTAGGGTTGGGATCCGTCAAGACACCGTGTCCAACTTTGAACTCCAGCCGGGAACGACCAAATTAGAGACTTTCT
TCAAAATCCTGTCTGCGCTGGATCTGGAGCTGGAAGTAAAACCCAGAGGTAGCCAGAGCTGCGAAACCAAAAGTACCGAT
GGTTGGAAAGAGGAGTGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0B6AMB9

References