Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazF-pemI/MazF(toxin) |
Location | 5210679..5211315 | Replicon | chromosome |
Accession | NZ_CP058255 | ||
Organism | Priestia megaterium strain BHS1 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | D5DWT4 |
Locus tag | HW369_RS27050 | Protein ID | WP_013055004.1 |
Coordinates | 5210679..5211029 (-) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | pemI | Uniprot ID | D5DWT3 |
Locus tag | HW369_RS27055 | Protein ID | WP_013055003.1 |
Coordinates | 5211034..5211315 (-) | Length | 94 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HW369_RS27015 | 5206261..5207055 | - | 795 | WP_013055011.1 | RNA polymerase sigma factor SigB | - |
HW369_RS27020 | 5207021..5207506 | - | 486 | WP_013055010.1 | anti-sigma B factor RsbW | - |
HW369_RS27025 | 5207503..5207835 | - | 333 | WP_013055009.1 | anti-sigma factor antagonist | - |
HW369_RS27030 | 5207895..5208905 | - | 1011 | WP_195695590.1 | PP2C family protein-serine/threonine phosphatase | - |
HW369_RS27035 | 5208919..5209320 | - | 402 | WP_013055007.1 | anti-sigma regulatory factor | - |
HW369_RS27040 | 5209324..5209680 | - | 357 | WP_013055006.1 | STAS domain-containing protein | - |
HW369_RS27045 | 5209683..5210519 | - | 837 | WP_013055005.1 | STAS domain-containing protein | - |
HW369_RS27050 | 5210679..5211029 | - | 351 | WP_013055004.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
HW369_RS27055 | 5211034..5211315 | - | 282 | WP_013055003.1 | hypothetical protein | Antitoxin |
HW369_RS27060 | 5211516..5212706 | - | 1191 | WP_195695591.1 | alanine racemase | - |
HW369_RS27065 | 5212820..5213878 | - | 1059 | WP_013055001.1 | outer membrane lipoprotein carrier protein LolA | - |
HW369_RS27070 | 5213937..5214302 | - | 366 | WP_025753519.1 | holo-ACP synthase | - |
HW369_RS27075 | 5214367..5214969 | + | 603 | WP_195695592.1 | rhomboid family intramembrane serine protease | - |
HW369_RS27080 | 5214978..5215949 | - | 972 | WP_195695593.1 | UV DNA damage repair endonuclease UvsE | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12991.96 Da Isoelectric Point: 4.8781
>T166421 WP_013055004.1 NZ_CP058255:c5211029-5210679 [Priestia megaterium]
MVVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVDEALQISVGLIDF
MVVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVDEALQISVGLIDF
Download Length: 351 bp
>T166421 NZ_CP074147:c5883171-5881852 [Serratia sp. JSRIV001]
ATGGCTGACCTAGATGTCTACATGAATGGTTATAAGGTAGGGATTTTCAGCCGTGAGGGCACTGGCGCCCATATGTTCCA
ATACGTGGACACTTGGCTTAACCAACCTGGAAGCCGTCCTATATCGCTCTCCATGCCCTTGAGGCGACGGCCTTACAAAG
GGGCAGAAGTCTACAACTTCTTCGATAACCTGCTGCCGGACAACCCTGAGATCCGGGGCAGGATCCTAGCCCGCTACCGT
GCTGACTCGACTCAACCCTTCGACCTTTTGGCACGTATCGGTGCTGACACCATTGGTGCACTGCAACTCTTGCCACAAAA
TGCAGGCCCGGGGGACATTCGCACCATAAACTATAAAGCGCTATCCAACCAAGAACTGGCAAGCATACTTACAGGCTACA
AAGCTGGTGCCCCTCTGGGCATGATTGAGGATGTTGAAGATTTCCGAATTTCCCTGGCCGGGGCCCAAGAAAAGACGGCT
CTCCTCTATCTCGAAAACCGTTGGTGTTTACCGATCGCAGCCACACCAACCACCCATATCATTAAGCTACCCATCGGAAA
AATAGAAAGCCACTCAAACAGTATCGACTTGTCAGACAGTGTCGAAAACGAGTATCTCTGCGCTCTAGTGGCCAAGGAAT
TTGGATTATCAGTCCCCCATTGCTTCATTATGCAAGTGGGTGACATAAAAGCCTTAGCAGTGGAACGCTTTGACCGCCGG
TATGCCTCGGACGGCAGTTGGATCATGCGACTGCCCCAAGAAGATTTCTGCCAGGTTTTAAATGTTCCCTCGGCACGTAA
ATACGAAAATCAGGGTGGTCCAGGGATAAGCGAGATCATGGAATATCTGCTTGGCTCGGTGACAGCGGAAAAGGATCGCT
ATAACTTCATGAAGGCACAGGTATTGTTCTGGTTGTTAGCCGCAACCGATGGACATGCAAAGAACTTCTCGGTGTTCATT
GAAGCTGATGGGCGTTTTCGTTTAACCCCCTTGTACGACATTCTATCTGTCTACCCGGTGTTTGCTGGCAGAGGCCTTCA
TCCGAAAGATGCCAAGCTCGCTATGGGCCTAAAAGGAAGCAAGGGAAAGAAGTACGCCATTGAGCAAATATTCCCACGCC
ACTTCTTCCACACAGCCAAAGCAGTGGGATTTGAGCGCGCCGCCATGGAGGGGATCCTGACGGAATTGGCTGAATCCGTT
GATACCGTCATCGAGCGGGTAACACAGCTGTTGCCAGCAGGTTTTCCTCCCGCCATCAGTAACGCCATTTTAAAGGGCCT
AAAAGCTCGTTCCGCAAGGCTGACAGTGGGCTGGGATTAG
ATGGCTGACCTAGATGTCTACATGAATGGTTATAAGGTAGGGATTTTCAGCCGTGAGGGCACTGGCGCCCATATGTTCCA
ATACGTGGACACTTGGCTTAACCAACCTGGAAGCCGTCCTATATCGCTCTCCATGCCCTTGAGGCGACGGCCTTACAAAG
GGGCAGAAGTCTACAACTTCTTCGATAACCTGCTGCCGGACAACCCTGAGATCCGGGGCAGGATCCTAGCCCGCTACCGT
GCTGACTCGACTCAACCCTTCGACCTTTTGGCACGTATCGGTGCTGACACCATTGGTGCACTGCAACTCTTGCCACAAAA
TGCAGGCCCGGGGGACATTCGCACCATAAACTATAAAGCGCTATCCAACCAAGAACTGGCAAGCATACTTACAGGCTACA
AAGCTGGTGCCCCTCTGGGCATGATTGAGGATGTTGAAGATTTCCGAATTTCCCTGGCCGGGGCCCAAGAAAAGACGGCT
CTCCTCTATCTCGAAAACCGTTGGTGTTTACCGATCGCAGCCACACCAACCACCCATATCATTAAGCTACCCATCGGAAA
AATAGAAAGCCACTCAAACAGTATCGACTTGTCAGACAGTGTCGAAAACGAGTATCTCTGCGCTCTAGTGGCCAAGGAAT
TTGGATTATCAGTCCCCCATTGCTTCATTATGCAAGTGGGTGACATAAAAGCCTTAGCAGTGGAACGCTTTGACCGCCGG
TATGCCTCGGACGGCAGTTGGATCATGCGACTGCCCCAAGAAGATTTCTGCCAGGTTTTAAATGTTCCCTCGGCACGTAA
ATACGAAAATCAGGGTGGTCCAGGGATAAGCGAGATCATGGAATATCTGCTTGGCTCGGTGACAGCGGAAAAGGATCGCT
ATAACTTCATGAAGGCACAGGTATTGTTCTGGTTGTTAGCCGCAACCGATGGACATGCAAAGAACTTCTCGGTGTTCATT
GAAGCTGATGGGCGTTTTCGTTTAACCCCCTTGTACGACATTCTATCTGTCTACCCGGTGTTTGCTGGCAGAGGCCTTCA
TCCGAAAGATGCCAAGCTCGCTATGGGCCTAAAAGGAAGCAAGGGAAAGAAGTACGCCATTGAGCAAATATTCCCACGCC
ACTTCTTCCACACAGCCAAAGCAGTGGGATTTGAGCGCGCCGCCATGGAGGGGATCCTGACGGAATTGGCTGAATCCGTT
GATACCGTCATCGAGCGGGTAACACAGCTGTTGCCAGCAGGTTTTCCTCCCGCCATCAGTAACGCCATTTTAAAGGGCCT
AAAAGCTCGTTCCGCAAGGCTGACAGTGGGCTGGGATTAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10691.22 Da Isoelectric Point: 8.5339
>AT166421 WP_013055003.1 NZ_CP058255:c5211315-5211034 [Priestia megaterium]
VSEASATTEILVRLPKNLVSELDLMVKQENGNRSDFIHQATKLYLRERKKRHIRESMRRGYMEMAKINLNIASEAFLAEY
EADHTVDRLVSGG
VSEASATTEILVRLPKNLVSELDLMVKQENGNRSDFIHQATKLYLRERKKRHIRESMRRGYMEMAKINLNIASEAFLAEY
EADHTVDRLVSGG
Download Length: 282 bp
>AT166421 NZ_CP074147:c5883431-5883171 [Serratia sp. JSRIV001]
ATGAAGATCACCAATGCCAAGCAGCTCAGCATCTACTTGCGAGATGTCCGCCTCGCAGAGAATCTTTCACAAGAAAAAGT
AGCCAGTAGGGTTGGGATCCGTCAAGACACCGTGTCCAACTTTGAACTCCAGCCGGGAACGACCAAATTAGAGACTTTCT
TCAAAATCCTGTCTGCGCTGGATCTGGAGCTGGAAGTAAAACCCAGAGGTAGCCAGAGCTGCGAAACCAAAAGTACCGAT
GGTTGGAAAGAGGAGTGGTAA
ATGAAGATCACCAATGCCAAGCAGCTCAGCATCTACTTGCGAGATGTCCGCCTCGCAGAGAATCTTTCACAAGAAAAAGT
AGCCAGTAGGGTTGGGATCCGTCAAGACACCGTGTCCAACTTTGAACTCCAGCCGGGAACGACCAAATTAGAGACTTTCT
TCAAAATCCTGTCTGCGCTGGATCTGGAGCTGGAAGTAAAACCCAGAGGTAGCCAGAGCTGCGAAACCAAAAGTACCGAT
GGTTGGAAAGAGGAGTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|