Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3839772..3840429 Replicon chromosome
Accession NZ_CP058253
Organism Enterobacter roggenkampii strain ED5

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag ED5_RS18000 Protein ID WP_021242050.1
Coordinates 3839772..3840182 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag ED5_RS18005 Protein ID WP_006178375.1
Coordinates 3840163..3840429 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ED5_RS17980 3835765..3837498 - 1734 WP_032653290.1 single-stranded-DNA-specific exonuclease RecJ -
ED5_RS17985 3837504..3838217 - 714 WP_008499708.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ED5_RS17990 3838246..3839142 - 897 WP_008499709.1 site-specific tyrosine recombinase XerD -
ED5_RS17995 3839244..3839765 + 522 WP_069598758.1 flavodoxin FldB -
ED5_RS18000 3839772..3840182 - 411 WP_021242050.1 protein YgfX Toxin
ED5_RS18005 3840163..3840429 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
ED5_RS18010 3840724..3841704 + 981 WP_087450575.1 tRNA-modifying protein YgfZ -
ED5_RS18015 3841789..3842448 - 660 WP_021242052.1 hemolysin III family protein -
ED5_RS18020 3842714..3843445 + 732 WP_021242053.1 MurR/RpiR family transcriptional regulator -
ED5_RS18025 3843562..3844995 + 1434 WP_023294510.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T166419 WP_021242050.1 NZ_CP058253:c3840182-3839772 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T166419 NZ_CP074147:5174043-5174324 [Serratia sp. JSRIV001]
ATGATTTATAAGCTCAAATTTGAAAAGCGCGCACTGAAGGAATGGGAAAAGCTGGGTTATCCCGTTCGGGAACAACTGAA
AAAGAAGCTGGCCGAGCGTTTAGAAAACCCGCATGTGCCGGCATCCCGCCTAAGTGGCCGCCCGAACCGTTACAAAATCA
AACTGCGCTCATCAGGCTATCGGTTGGTTTATGAAGTACGTGATAATGAAATTGTTCTATTGGTGATCGCCGTTGGAAAA
CGGGCTGGGGAGGAAGTCTATTTTGCTGCCGATAAGCGATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT166419 WP_006178375.1 NZ_CP058253:c3840429-3840163 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT166419 NZ_CP074147:5173802-5174053 [Serratia sp. JSRIV001]
ATGGCCTTTCAAATTTTAACCACTATCGCTGCCAGCATCACCGACCTGAAAAAGAACCCGATGGGAACCGTTGCAGACGG
AGAAGGTGAAGCGGTTGCCATCCTGAATCGTAACGAACCGGCTTTCTACTGCGTGCCCCCTGAGCTGTATGCATACTATC
GGGAGCTTGCCGAAGATGCAGAATTAAACCGTATTGCAGATGAACGCATGGAAGATGCGGAGTTTGTGAGCGTAAATCTT
AATGATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References