Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1667429..1668226 Replicon chromosome
Accession NZ_CP058253
Organism Enterobacter roggenkampii strain ED5

Toxin (Protein)


Gene name KacT Uniprot ID A0A155TD66
Locus tag ED5_RS07815 Protein ID WP_032651255.1
Coordinates 1667705..1668226 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID W7PG43
Locus tag ED5_RS07810 Protein ID WP_008499829.1
Coordinates 1667429..1667698 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ED5_RS07780 1663052..1663495 - 444 WP_008499834.1 helix-turn-helix transcriptional regulator -
ED5_RS07785 1663648..1664889 + 1242 WP_008499833.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
ED5_RS07790 1664925..1665152 - 228 WP_008499832.1 YccJ family protein -
ED5_RS07795 1665173..1665769 - 597 WP_008499831.1 NAD(P)H:quinone oxidoreductase -
ED5_RS07800 1666161..1666331 + 171 WP_013097201.1 general stress protein -
ED5_RS07805 1666450..1667367 + 918 WP_025912980.1 DMT family transporter -
ED5_RS07810 1667429..1667698 + 270 WP_008499829.1 DUF1778 domain-containing protein Antitoxin
ED5_RS07815 1667705..1668226 + 522 WP_032651255.1 GNAT family N-acetyltransferase Toxin
ED5_RS07820 1668300..1669622 - 1323 WP_177317292.1 pyrimidine utilization transport protein G -
ED5_RS07825 1669644..1670138 - 495 WP_177317293.1 pyrimidine utilization flavin reductase protein F -
ED5_RS07830 1670148..1670738 - 591 WP_177317294.1 malonic semialdehyde reductase -
ED5_RS07835 1670748..1671548 - 801 WP_177317295.1 pyrimidine utilization protein D -
ED5_RS07840 1671556..1671942 - 387 WP_008499822.1 pyrimidine utilization protein C -
ED5_RS07845 1671954..1672643 - 690 WP_177317296.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19714.46 Da        Isoelectric Point: 7.0497

>T166410 WP_032651255.1 NZ_CP058253:1667705-1668226 [Enterobacter roggenkampii]
VDNLTIEMFSEGKDYDFRDFDCGEPSLNVFLTEHLVRQHNGRILRGYLLKDRDGPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAIHKDLQGLEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNDQAKQFYLKQGFIPLTDENSHSLF
FPTKSIERLFEQA

Download         Length: 522 bp

>T166410 NZ_CP074147:c4261343-4260954 [Serratia sp. JSRIV001]
ATGTATATGTTCGACACTAACACGGTGAGCCAGCTTTTTCGTCAACATCCCCGGCTGCTTGCGGCTATGGGCCGGGTACC
GCCATCGTCGGTGTGTATTTCCAGCATAACCCAGGCGGAACTGCTTTATGGTGTCGCCAAGCGGCAGAACAAGGCGCTAA
AACAGACGGTGATGATGTTCCTGGACGCCGTCACCGTTTACTCCTGGGACTCTGCGGCGGCGCATTGCTATGGTGTCATG
CGCGCAAGTATGGAAAAACAAGGCAGACCGATGGGGGCGTTGGATCAGCTTATTGCCGCACATGCGGTAAGCCGTGGCGC
AACCATAGTGACCAGCGATCGGGCTTTCACTATGGTCGCGGAGCTTGAGGTGGAAGACTGGACGCTGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10262.72 Da        Isoelectric Point: 5.8836

>AT166410 WP_008499829.1 NZ_CP058253:1667429-1667698 [Enterobacter roggenkampii]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp

>AT166410 NZ_CP074147:c4261610-4261347 [Serratia sp. JSRIV001]
ATGGAAAGAGTCGCCAAGCTTTTTAAAAACGGTAGAAATCAGGCGGTGAGATTGCCAGTGGAATTCGAATTCGATGTCGA
TCAGGTTTATATTCGCCGGGATGAACAGGGTAACGTTATCTTGTCGAAGCATCCAATGAAATTGGACTCCTGGCAACCGC
TACTGACCATGCTGCAAAACGTGGCGGTTCCTGCTGACTTCCTGACTGCTGACGATCGCCAGCAAGGGGTAGCAGAACGG
GATCCGTTCAAGGAGGAACAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A155TD66

Antitoxin

Source ID Structure
AlphaFold DB W7PG43

References